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Increased amyloid-beta42(43) in brains of mice expressing mutant presenilin 1.
Duff K, Eckman C, Zehr C, Yu X, Prada CM, Perez-tur J, Hutton M, Buee L, Harigaya Y, Yager D, Morgan D, Gordon MN, Holcomb L, Refolo L, Zenk B, Hardy J, Younkin S. Duff K, et al. Among authors: hutton m. Nature. 1996 Oct 24;383(6602):710-3. doi: 10.1038/383710a0. Nature. 1996. PMID: 8878479
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease.
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N, Bird TD, Hardy J, Hutton M, Kukull W, Larson E, Levy-Lahad E, Viitanen M, Peskind E, Poorkaj P, Schellenberg G, Tanzi R, Wasco W, Lannfelt L, Selkoe D, Younkin S. Scheuner D, et al. Among authors: hutton m. Nat Med. 1996 Aug;2(8):864-70. doi: 10.1038/nm0896-864. Nat Med. 1996. PMID: 8705854
Complete analysis of the presenilin 1 gene in early onset Alzheimer's disease.
Hutton M, Busfield F, Wragg M, Crook R, Perez-Tur J, Clark RF, Prihar G, Talbot C, Phillips H, Wright K, Baker M, Lendon C, Duff K, Martinez A, Houlden H, Nichols A, Karran E, Roberts G, Roques P, Rossor M, Venter JC, Adams MD, Cline RT, Phillips CA, Goate A, et al. Hutton M, et al. Neuroreport. 1996 Feb 29;7(3):801-5. doi: 10.1097/00001756-199602290-00029. Neuroreport. 1996. PMID: 8733749
Structure and alternative splicing of the presenilin-2 gene.
Prihar G, Fuldner RA, Perez-Tur J, Lincoln S, Duff K, Crook R, Hardy J, Philips CA, Venter C, Talbot C, Clark RF, Goate A, Li J, Potter H, Karran E, Roberts GW, Hutton M, Adams MD. Prihar G, et al. Among authors: hutton m. Neuroreport. 1996 Jul 8;7(10):1680-4. doi: 10.1097/00001756-199607080-00031. Neuroreport. 1996. PMID: 8904781
The presenilins and Alzheimer's disease.
Hutton M, Hardy J. Hutton M, et al. Hum Mol Genet. 1997;6(10):1639-46. doi: 10.1093/hmg/6.10.1639. Hum Mol Genet. 1997. PMID: 9300655 Review.
482 results