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Page 1
N-aryl-3,3,3-trifluoro-2-hydroxy-2-methylpropanamides: KATP potassium channel openers. Modifications on the western region.
Ohnmacht CJ, Russell K, Empfield JR, Frank CA, Gibson KH, Mayhugh DR, McLaren FM, Shapiro HS, Brown FJ, Trainor DA, Ceccarelli C, Lin MM, Masek BB, Forst JM, Harris RJ, Hulsizer JM, Lewis JJ, Silverman SM, Smith RW, Warwick PJ, Kau ST, Chun AL, Grant TL, Howe BB, Neilson KL, et al. Ohnmacht CJ, et al. Among authors: forst jm. J Med Chem. 1996 Nov 8;39(23):4592-601. doi: 10.1021/jm960365n. J Med Chem. 1996. PMID: 8917648
Pyridazinoquinolinetriones as NMDA glycine-site antagonists with oral antinociceptive activity in a model of neuropathic pain.
Bare TM, Brown DG, Horchler CL, Murphy M, Urbanek RA, Alford V, Barlaam C, Dyroff MC, Empfield JB, Forst JM, Herzog KJ, Keith RA, Kirschner AS, Lee CM, Lewis J, McLaren FM, Neilson KL, Steelman GB, Trivedi S, Vacek EP, Xiao W. Bare TM, et al. Among authors: forst jm. J Med Chem. 2007 Jun 28;50(13):3113-31. doi: 10.1021/jm060212s. Epub 2007 Jun 2. J Med Chem. 2007. PMID: 17542571
Synthesis of 7-chloro-2,3-dihydro-2-[1-(pyridinyl)alkyl]-pyridazino[4,5-b]quinoline-1,4,10(5H)-triones as NMDA glycine-site antagonists.
Brown DG, Urbanek RA, Bare TM, McLaren FM, Horchler CL, Murphy M, Steelman GB, Empfield JR, Forst JM, Herzog KJ, Xiao W, Dyroff MC, Lee CM, Trivedi S, Neilson KL, Keith RA. Brown DG, et al. Among authors: forst jm. Bioorg Med Chem Lett. 2003 Oct 20;13(20):3553-6. doi: 10.1016/s0960-894x(03)00750-9. Bioorg Med Chem Lett. 2003. PMID: 14505669
Bicyclo((aryl)methyl)benzamides as inhibitors of GlyT1.
Varnes JG, Xiong H, Forst JM, Holmquist CR, Ernst GE, Frietze W, Dembofsky B, Andisik DW, Palmer WE, Hinkley L, Steelman GB, Wilkins DE, Tian G, Jonak G, Potts WM, Wang X, Brugel TA, Alhambra C, Wood MW, Veale CA, Albert JS. Varnes JG, et al. Among authors: forst jm. Bioorg Med Chem Lett. 2018 Apr 1;28(6):1043-1049. doi: 10.1016/j.bmcl.2018.02.029. Epub 2018 Feb 14. Bioorg Med Chem Lett. 2018. PMID: 29486970