Hawkinson JE - Search Results

1

Analogs of 3-hydroxy-1H-1-benzazepine-2,5-dione: structure-activity relationship at N-methyl-D-aspartate receptor glycine sites.

Guzikowski AP, Cai SX, Espitia SA, Hawkinson JE, Huettner JE, Nogales DF, Tran M, Woodward RM, Weber E, Keana JF. Guzikowski AP, et al. Among authors: hawkinson je. J Med Chem. 1996 Nov 8;39(23):4643-53. doi: 10.1021/jm960479z. J Med Chem. 1996. PMID: 8917653

2

Correlation of neuroactive steroid modulation of [35S]t-butylbicyclophosphorothionate and [3H]flunitrazepam binding and gamma-aminobutyric acidA receptor function.

Hawkinson JE, Kimbrough CL, Belelli D, Lambert JJ, Purdy RH, Lan NC. Hawkinson JE, et al. Mol Pharmacol. 1994 Nov;46(5):977-85. Mol Pharmacol. 1994. PMID: 7969089

3

3 alpha-Hydroxy-3 beta-trifluoromethyl-5 alpha-pregnan-20-one (Co 2-1970): a partial agonist at the neuroactive steroid site of the gamma-aminobutyric acidA receptor.

Hawkinson JE, Drewe JA, Kimbrough CL, Chen JS, Hogenkamp DJ, Lan NC, Gee KW, Shen KZ, Whittemore ER, Woodward RM. Hawkinson JE, et al. Mol Pharmacol. 1996 May;49(5):897-906. Mol Pharmacol. 1996. PMID: 8622640

4

Synthesis and structure-activity relationships of 1,2,3,4-tetrahydroquinoline-2,3,4-trione 3-oximes: novel and highly potent antagonists for NMDA receptor glycine site.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Lü Y, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1996 Aug 16;39(17):3248-55. doi: 10.1021/jm960214k. J Med Chem. 1996. PMID: 8765507

5

Structure-activity relationships of 4-hydroxy-3-nitroquinolin-2(1H)-ones as novel antagonists at the glycine site of N-methyl-D-aspartate receptors.

Cai SX, Zhou ZL, Huang JC, Whittemore ER, Egbuwoku ZO, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1996 Nov 8;39(23):4682-6. doi: 10.1021/jm960520y. J Med Chem. 1996. PMID: 8917657

6

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.

Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB. Hogenkamp DJ, et al. Among authors: hawkinson je. J Med Chem. 1997 Jan 3;40(1):61-72. doi: 10.1021/jm960021x. J Med Chem. 1997. PMID: 9016329

7

3 alpha-Hydroxy-3 beta-(phenylethynyl)-5 beta-pregnan-20-ones: synthesis and pharmacological activity of neuroactive steroids with high affinity for GABAA receptors.

Upasani RB, Yang KC, Acosta-Burruel M, Konkoy CS, McLellan JA, Woodward RM, Lan NC, Carter RB, Hawkinson JE. Upasani RB, et al. Among authors: hawkinson je. J Med Chem. 1997 Jan 3;40(1):73-84. doi: 10.1021/jm9605344. J Med Chem. 1997. PMID: 9016330

8

The N-methyl-D-aspartate (NMDA) receptor glycine site antagonist ACEA 1021 does not produce pathological changes in rat brain.

Hawkinson JE, Huber KR, Sahota PS, Han Hsu H, Weber E, Whitehouse MJ. Hawkinson JE, et al. Brain Res. 1997 Jan 9;744(2):227-34. doi: 10.1016/S0006-8993(96)01064-5. Brain Res. 1997. PMID: 9027382

9

Structure-activity relationships of alkyl- and alkoxy-substituted 1,4-dihydroquinoxaline-2,3-diones: potent and systemically active antagonists for the glycine site of the NMDA receptor.

Cai SX, Kher SM, Zhou ZL, Ilyin V, Espitia SA, Tran M, Hawkinson JE, Woodward RM, Weber E, Keana JF. Cai SX, et al. Among authors: hawkinson je. J Med Chem. 1997 Feb 28;40(5):730-8. doi: 10.1021/jm960654b. J Med Chem. 1997. PMID: 9057859

10

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW. Carter RB, et al. Among authors: hawkinson je. J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95. J Pharmacol Exp Ther. 1997. PMID: 9067315

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