Leeson PD - Search Results

1

Anticonvulsant and behavioral profile of L-701,324, a potent, orally active antagonist at the glycine modulatory site on the N-methyl-D-aspartate receptor complex.

Bristow LJ, Hutson PH, Kulagowski JJ, Leeson PD, Matheson S, Murray F, Rathbone D, Saywell KL, Thorn L, Watt AP, Tricklebank MD. Bristow LJ, et al. Among authors: leeson pd. J Pharmacol Exp Ther. 1996 Nov;279(2):492-501. J Pharmacol Exp Ther. 1996. PMID: 8930150

2

Allosteric modulation of the glutamate site on the NMDA receptor by four novel glycine site antagonists.

Grimwood S, Kulagowski JJ, Mawer IM, Rowley M, Leeson PD, Foster AC. Grimwood S, et al. Among authors: leeson pd. Eur J Pharmacol. 1995 Aug 15;290(3):221-6. doi: 10.1016/0922-4106(95)00081-x. Eur J Pharmacol. 1995. PMID: 7589216

3

The anticonvulsant and behavioural profile of L-687,414, a partial agonist acting at the glycine modulatory site on the N-methyl-D-aspartate (NMDA) receptor complex.

Tricklebank MD, Bristow LJ, Hutson PH, Leeson PD, Rowley M, Saywell K, Singh L, Tattersall FD, Thorn L, Williams BJ. Tricklebank MD, et al. Among authors: leeson pd. Br J Pharmacol. 1994 Nov;113(3):729-36. doi: 10.1111/j.1476-5381.1994.tb17054.x. Br J Pharmacol. 1994. PMID: 7858861 Free PMC article.

4

The atypical neuroleptic profile of the glycine/N-methyl-D-aspartate receptor antagonist, L-701,324, in rodents.

Bristow LJ, Flatman KL, Hutson PH, Kulagowski JJ, Leeson PD, Young L, Tricklebank MD. Bristow LJ, et al. Among authors: leeson pd. J Pharmacol Exp Ther. 1996 May;277(2):578-85. J Pharmacol Exp Ther. 1996. PMID: 8627534

5

4-substituted-3-phenylquinolin-2(1H)-ones: acidic and nonacidic glycine site N-methyl-D-aspartate antagonists with in vivo activity.

Carling RW, Leeson PD, Moore KW, Moyes CR, Duncton M, Hudson ML, Baker R, Foster AC, Grimwood S, Kemp JA, Marshall GR, Tricklebank MD, Saywell KL. Carling RW, et al. Among authors: leeson pd. J Med Chem. 1997 Feb 28;40(5):754-65. doi: 10.1021/jm9605492. J Med Chem. 1997. PMID: 9057862

6

Biological profile of L-745,870, a selective antagonist with high affinity for the dopamine D4 receptor.

Patel S, Freedman S, Chapman KL, Emms F, Fletcher AE, Knowles M, Marwood R, Mcallister G, Myers J, Curtis N, Kulagowski JJ, Leeson PD, Ridgill M, Graham M, Matheson S, Rathbone D, Watt AP, Bristow LJ, Rupniak NM, Baskin E, Lynch JJ, Ragan CI. Patel S, et al. Among authors: leeson pd. J Pharmacol Exp Ther. 1997 Nov;283(2):636-47. J Pharmacol Exp Ther. 1997. PMID: 9353380

7

L-745,870, a subtype selective dopamine D4 receptor antagonist, does not exhibit a neuroleptic-like profile in rodent behavioral tests.

Bristow LJ, Collinson N, Cook GP, Curtis N, Freedman SB, Kulagowski JJ, Leeson PD, Patel S, Ragan CI, Ridgill M, Saywell KL, Tricklebank MD. Bristow LJ, et al. Among authors: leeson pd. J Pharmacol Exp Ther. 1997 Dec;283(3):1256-63. J Pharmacol Exp Ther. 1997. PMID: 9400001

8

Effect of plasma protein binding on in vivo activity and brain penetration of glycine/NMDA receptor antagonists.

Rowley M, Kulagowski JJ, Watt AP, Rathbone D, Stevenson GI, Carling RW, Baker R, Marshall GR, Kemp JA, Foster AC, Grimwood S, Hargreaves R, Hurley C, Saywell KL, Tricklebank MD, Leeson PD. Rowley M, et al. Among authors: leeson pd. J Med Chem. 1997 Dec 5;40(25):4053-68. doi: 10.1021/jm970417o. J Med Chem. 1997. PMID: 9406596

9

Enantiomers of HA-966 (3-amino-1-hydroxypyrrolid-2-one) exhibit distinct central nervous system effects: (+)-HA-966 is a selective glycine/N-methyl-D-aspartate receptor antagonist, but (-)-HA-966 is a potent gamma-butyrolactone-like sedative.

Singh L, Donald AE, Foster AC, Hutson PH, Iversen LL, Iversen SD, Kemp JA, Leeson PD, Marshall GR, Oles RJ, et al. Singh L, et al. Among authors: leeson pd. Proc Natl Acad Sci U S A. 1990 Jan;87(1):347-51. doi: 10.1073/pnas.87.1.347. Proc Natl Acad Sci U S A. 1990. PMID: 2153294 Free PMC article.

10

3'-(Arylmethyl)- and 3'-(aryloxy)-3-phenyl-4-hydroxyquinolin-2(1H)-ones: orally active antagonists of the glycine site on the NMDA receptor.

Kulagowski JJ, Baker R, Curtis NR, Leeson PD, Mawer IM, Moseley AM, Ridgill MP, Rowley M, Stansfield I, Foster AC, et al. Kulagowski JJ, et al. Among authors: leeson pd. J Med Chem. 1994 May 13;37(10):1402-5. doi: 10.1021/jm00036a002. J Med Chem. 1994. PMID: 8182696 No abstract available.

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