Romero DL - Search Results

1

Synthesis and bioactivity of novel bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships and increased metabolic stability of novel substituted pyridine analogs.

Genin MJ, Poel TJ, Yagi Y, Biles C, Althaus I, Keiser BJ, Kopta LA, Friis JM, Reusser F, Adams WJ, Olmsted RA, Voorman RL, Thomas RC, Romero DL. Genin MJ, et al. Among authors: romero dl. J Med Chem. 1996 Dec 20;39(26):5267-75. doi: 10.1021/jm960269m. J Med Chem. 1996. PMID: 8978855

2

Discovery, synthesis, and bioactivity of bis(heteroaryl)piperazines. 1. A novel class of non-nucleoside HIV-1 reverse transcriptase inhibitors.

Romero DL, Morge RA, Biles C, Berrios-Pena N, May PD, Palmer JR, Johnson PD, Smith HW, Busso M, Tan CK, et al. Romero DL, et al. J Med Chem. 1994 Apr 1;37(7):999-1014. doi: 10.1021/jm00033a018. J Med Chem. 1994. PMID: 7512142

3

Bis(heteroaryl)piperazine (BHAP) reverse transcriptase inhibitors: structure-activity relationships of novel substituted indole analogues and the identification of 1-[(5-methanesulfonamido-1H-indol-2-yl)-carbonyl]-4-[3- [(1-methylethyl)amino]-pyridinyl]piperazine monomethanesulfonate (U-90152S), a second-generation clinical candidate.

Romero DL, Morge RA, Genin MJ, Biles C, Busso M, Resnick L, Althaus IW, Reusser F, Thomas RC, Tarpley WG. Romero DL, et al. J Med Chem. 1993 May 14;36(10):1505-8. doi: 10.1021/jm00062a027. J Med Chem. 1993. PMID: 7684450 No abstract available.

4

(Alkylamino) piperidine bis(heteroaryl)piperizine analogs are potent, broad-spectrum nonnucleoside reverse transcriptase inhibitors of drug-resistant isolates of human immunodeficiency virus type 1 (HIV-1) and select for drug-resistant variants of HIV-1IIIB with reduced replication phenotypes.

Olmsted RA, Slade DE, Kopta LA, Poppe SM, Poel TJ, Newport SW, Rank KB, Biles C, Morge RA, Dueweke TJ, Yagi Y, Romero DL, Thomas RC, Sharma SK, Tarpley WG. Olmsted RA, et al. Among authors: romero dl. J Virol. 1996 Jun;70(6):3698-705. doi: 10.1128/JVI.70.6.3698-3705.1996. J Virol. 1996. PMID: 8648704 Free PMC article.

5

Targeting delavirdine/atevirdine resistant HIV-1: identification of (alkylamino)piperidine-containing bis(heteroaryl)piperazines as broad spectrum HIV-1 reverse transcriptase inhibitors.

Romero DL, Olmsted RA, Poel TJ, Morge RA, Biles C, Keiser BJ, Kopta LA, Friis JM, Hosley JD, Stefanski KJ, Wishka DG, Evans DB, Morris J, Stehle RG, Sharma SK, Yagi Y, Voorman RL, Adams WJ, Tarpley WG, Thomas RC. Romero DL, et al. J Med Chem. 1996 Sep 13;39(19):3769-89. doi: 10.1021/jm960158n. J Med Chem. 1996. PMID: 8809165

6

Synthesis and structure-activity relationships of the (alkylamino)piperidine-containing BHAP class of non-nucleoside reverse transcriptase inhibitors: effect of 3-alkylpyridine ring substitution.

Genin MJ, Poel TJ, May PD, Kopta LA, Yagi Y, Olmsted RA, Friis JM, Voorman RL, Adams WJ, Thomas RC, Romero DL. Genin MJ, et al. Among authors: romero dl. J Med Chem. 1999 Oct 7;42(20):4140-9. doi: 10.1021/jm990051a. J Med Chem. 1999. PMID: 10514284

7

Novel 1,5-diphenylpyrazole nonnucleoside HIV-1 reverse transcriptase inhibitors with enhanced activity versus the delavirdine-resistant P236L mutant: lead identification and SAR of 3- and 4-substituted derivatives.

Genin MJ, Biles C, Keiser BJ, Poppe SM, Swaney SM, Tarpley WG, Yagi Y, Romero DL. Genin MJ, et al. Among authors: romero dl. J Med Chem. 2000 Mar 9;43(5):1034-40. doi: 10.1021/jm990383f. J Med Chem. 2000. PMID: 10715167

8

Nonnucleoside reverse transcriptase inhibitors that potently and specifically block human immunodeficiency virus type 1 replication.

Romero DL, Busso M, Tan CK, Reusser F, Palmer JR, Poppe SM, Aristoff PA, Downey KM, So AG, Resnick L, et al. Romero DL, et al. Proc Natl Acad Sci U S A. 1991 Oct 1;88(19):8806-10. doi: 10.1073/pnas.88.19.8806. Proc Natl Acad Sci U S A. 1991. PMID: 1717988 Free PMC article.

9

Kinetic studies with the non-nucleoside human immunodeficiency virus type-1 reverse transcriptase inhibitor U-90152E.

Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Thomas RC, Aristoff PA, Tarpley WG, et al. Althaus IW, et al. Among authors: romero dl. Biochem Pharmacol. 1994 Jun 1;47(11):2017-28. doi: 10.1016/0006-2952(94)90077-9. Biochem Pharmacol. 1994. PMID: 7516658

10

Steady-state kinetic studies with the non-nucleoside HIV-1 reverse transcriptase inhibitor U-87201E.

Althaus IW, Chou JJ, Gonzales AJ, Deibel MR, Chou KC, Kezdy FJ, Romero DL, Aristoff PA, Tarpley WG, Reusser F. Althaus IW, et al. Among authors: romero dl. J Biol Chem. 1993 Mar 25;268(9):6119-24. J Biol Chem. 1993. PMID: 7681060 Free article.

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