Witthuhn BA - Search Results

1

A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses.

Kohlhuber F, Rogers NC, Watling D, Feng J, Guschin D, Briscoe J, Witthuhn BA, Kotenko SV, Pestka S, Stark GR, Ihle JN, Kerr IM. Kohlhuber F, et al. Among authors: witthuhn ba. Mol Cell Biol. 1997 Feb;17(2):695-706. doi: 10.1128/MCB.17.2.695. Mol Cell Biol. 1997. PMID: 9001223 Free PMC article.

2

A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6.

Guschin D, Rogers N, Briscoe J, Witthuhn B, Watling D, Horn F, Pellegrini S, Yasukawa K, Heinrich P, Stark GR, et al. Guschin D, et al. EMBO J. 1995 Apr 3;14(7):1421-9. doi: 10.1002/j.1460-2075.1995.tb07128.x. EMBO J. 1995. PMID: 7537214 Free PMC article.

3

Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway.

Watling D, Guschin D, Müller M, Silvennoinen O, Witthuhn BA, Quelle FW, Rogers NC, Schindler C, Stark GR, Ihle JN, et al. Watling D, et al. Among authors: witthuhn ba. Nature. 1993 Nov 11;366(6451):166-70. doi: 10.1038/366166a0. Nature. 1993. PMID: 7901766

4

Activation of JAK kinases and STAT proteins by interleukin-2 and interferon alpha, but not the T cell antigen receptor, in human T lymphocytes.

Beadling C, Guschin D, Witthuhn BA, Ziemiecki A, Ihle JN, Kerr IM, Cantrell DA. Beadling C, et al. Among authors: witthuhn ba. EMBO J. 1994 Dec 1;13(23):5605-15. doi: 10.1002/j.1460-2075.1994.tb06898.x. EMBO J. 1994. PMID: 7988557 Free PMC article.

5

The protein tyrosine kinase JAK1 complements defects in interferon-alpha/beta and -gamma signal transduction.

Müller M, Briscoe J, Laxton C, Guschin D, Ziemiecki A, Silvennoinen O, Harpur AG, Barbieri G, Witthuhn BA, Schindler C, et al. Müller M, et al. Among authors: witthuhn ba. Nature. 1993 Nov 11;366(6451):129-35. doi: 10.1038/366129a0. Nature. 1993. PMID: 8232552

6

Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state.

Briscoe J, Rogers NC, Witthuhn BA, Watling D, Harpur AG, Wilks AF, Stark GR, Ihle JN, Kerr IM. Briscoe J, et al. Among authors: witthuhn ba. EMBO J. 1996 Feb 15;15(4):799-809. EMBO J. 1996. PMID: 8631301 Free PMC article.

7

Activation of Jak2 catalytic activity requires phosphorylation of Y1007 in the kinase activation loop.

Feng J, Witthuhn BA, Matsuda T, Kohlhuber F, Kerr IM, Ihle JN. Feng J, et al. Among authors: witthuhn ba. Mol Cell Biol. 1997 May;17(5):2497-501. doi: 10.1128/MCB.17.5.2497. Mol Cell Biol. 1997. PMID: 9111318 Free PMC article.

8

JAK2 associates with the beta c chain of the receptor for granulocyte-macrophage colony-stimulating factor, and its activation requires the membrane-proximal region.

Quelle FW, Sato N, Witthuhn BA, Inhorn RC, Eder M, Miyajima A, Griffin JD, Ihle JN. Quelle FW, et al. Among authors: witthuhn ba. Mol Cell Biol. 1994 Jul;14(7):4335-41. doi: 10.1128/mcb.14.7.4335-4341.1994. Mol Cell Biol. 1994. PMID: 8007942 Free PMC article.

9

Determination of the transphosphorylation sites of Jak2 kinase.

Matsuda T, Feng J, Witthuhn BA, Sekine Y, Ihle JN. Matsuda T, et al. Among authors: witthuhn ba. Biochem Biophys Res Commun. 2004 Dec 10;325(2):586-94. doi: 10.1016/j.bbrc.2004.10.071. Biochem Biophys Res Commun. 2004. PMID: 15530433 Free article.

10

A kinase-deficient splice variant of the human JAK3 is expressed in hematopoietic and epithelial cancer cells.

Lai KS, Jin Y, Graham DK, Witthuhn BA, Ihle JN, Liu ET. Lai KS, et al. Among authors: witthuhn ba. J Biol Chem. 1995 Oct 20;270(42):25028-36. doi: 10.1074/jbc.270.42.25028. J Biol Chem. 1995. PMID: 7559633 Free article.

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