Directional selection associated with clonal expansion of p53 mutant cells during neoplastic development of carcinogen-treated rat embryo lung epithelial cells.
Le Rhun Y, Duthu A, Ehrhart JC, Michiels F, May E, May P.
Le Rhun Y, et al. Among authors: may e, may p.
Oncogene. 1994 Jan;9(1):263-71.
Oncogene. 1994.
PMID: 8302588
In this study, rat embryo lung organ cultures were exposed to benzo[a]pyrene (B[a]P). After carcinogen-treatment the cells were dissociated and an epithelial cell line (BP) was developed from the primary cell culture derived from the carcinogen-treated explants. ...The pat …
In this study, rat embryo lung organ cultures were exposed to benzo[a]pyrene (B[a]P). After carcinogen-treatment the cells were disso …