Bolger MB - Search Results

1

Synthesis and in vitro activity of 3 beta-substituted-3 alpha-hydroxypregnan-20-ones: allosteric modulators of the GABAA receptor.

Hogenkamp DJ, Tahir SH, Hawkinson JE, Upasani RB, Alauddin M, Kimbrough CL, Acosta-Burruel M, Whittemore ER, Woodward RM, Lan NC, Gee KW, Bolger MB. Hogenkamp DJ, et al. Among authors: bolger mb. J Med Chem. 1997 Jan 3;40(1):61-72. doi: 10.1021/jm960021x. J Med Chem. 1997. PMID: 9016329

2

The neuroactive steroid 3 alpha-hydroxy-5 beta-pregnan-20-one is a two-component modulator of ligand binding to the GABAA receptor.

Hawkinson JE, Kimbrough CL, McCauley LD, Bolger MB, Lan NC, Gee KW. Hawkinson JE, et al. Among authors: bolger mb. Eur J Pharmacol. 1994 Oct 14;269(2):157-63. doi: 10.1016/0922-4106(94)90082-5. Eur J Pharmacol. 1994. PMID: 7851492

3

Characterization of the anticonvulsant properties of ganaxolone (CCD 1042; 3alpha-hydroxy-3beta-methyl-5alpha-pregnan-20-one), a selective, high-affinity, steroid modulator of the gamma-aminobutyric acid(A) receptor.

Carter RB, Wood PL, Wieland S, Hawkinson JE, Belelli D, Lambert JJ, White HS, Wolf HH, Mirsadeghi S, Tahir SH, Bolger MB, Lan NC, Gee KW. Carter RB, et al. Among authors: bolger mb. J Pharmacol Exp Ther. 1997 Mar;280(3):1284-95. J Pharmacol Exp Ther. 1997. PMID: 9067315

4

Pharmacology of a GABAA receptor coupled steroid recognition site.

Gee KW, Lan NC, Bolger MB, Wieland S, Belelli D, Chen JS. Gee KW, et al. Among authors: bolger mb. Adv Biochem Psychopharmacol. 1992;47:111-7. Adv Biochem Psychopharmacol. 1992. PMID: 1354914 Review. No abstract available.

5

Differential responses of expressed recombinant human gamma-aminobutyric acidA receptors to neurosteroids.

Lan NC, Gee KW, Bolger MB, Chen JS. Lan NC, et al. Among authors: bolger mb. J Neurochem. 1991 Nov;57(5):1818-21. doi: 10.1111/j.1471-4159.1991.tb06388.x. J Neurochem. 1991. PMID: 1655982

6

Identification and characterization of a pregnane steroid recognition site that is functionally coupled to an expressed GABAA receptor.

Lan NC, Bolger MB, Gee KW. Lan NC, et al. Among authors: bolger mb. Neurochem Res. 1991 Mar;16(3):347-56. doi: 10.1007/BF00966098. Neurochem Res. 1991. PMID: 1664061 Review. No abstract available.

7

Steroid modulation of the chloride ionophore in rat brain: structure-activity requirements, regional dependence and mechanism of action.

Gee KW, Bolger MB, Brinton RE, Coirini H, McEwen BS. Gee KW, et al. Among authors: bolger mb. J Pharmacol Exp Ther. 1988 Aug;246(2):803-12. J Pharmacol Exp Ther. 1988. PMID: 2841455

8

In vitro and in vivo activity of 16,17-dehydro-epipregnanolones: 17,20-bond torsional energy analysis and D-ring conformation.

Bolger MB, Wieland S, Hawkinson JE, Xia H, Upasani R, Lan NC. Bolger MB, et al. Pharm Res. 1996 Oct;13(10):1488-94. doi: 10.1023/a:1016019327120. Pharm Res. 1996. PMID: 8899839

9

Anticonvulsant profile of the progesterone metabolite 5 alpha-pregnan-3 alpha-ol-20-one.

Belelli D, Bolger MB, Gee KW. Belelli D, et al. Among authors: bolger mb. Eur J Pharmacol. 1989 Jul 18;166(2):325-9. doi: 10.1016/0014-2999(89)90077-0. Eur J Pharmacol. 1989. PMID: 2792198

10

Discovery of structurally diverse HIV-1 integrase inhibitors based on a chalcone pharmacophore.

Deng J, Sanchez T, Al-Mawsawi LQ, Dayam R, Yunes RA, Garofalo A, Bolger MB, Neamati N. Deng J, et al. Among authors: bolger mb. Bioorg Med Chem. 2007 Jul 15;15(14):4985-5002. doi: 10.1016/j.bmc.2007.04.041. Epub 2007 Apr 25. Bioorg Med Chem. 2007. PMID: 17502148

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