Shimano H - Search Results

1

Differential expression of exons 1a and 1c in mRNAs for sterol regulatory element binding protein-1 in human and mouse organs and cultured cells.

Shimomura I, Shimano H, Horton JD, Goldstein JL, Brown MS. Shimomura I, et al. Among authors: shimano h. J Clin Invest. 1997 Mar 1;99(5):838-45. doi: 10.1172/JCI119247. J Clin Invest. 1997. PMID: 9062340 Free PMC article.

2

Overproduction of cholesterol and fatty acids causes massive liver enlargement in transgenic mice expressing truncated SREBP-1a.

Shimano H, Horton JD, Hammer RE, Shimomura I, Brown MS, Goldstein JL. Shimano H, et al. J Clin Invest. 1996 Oct 1;98(7):1575-84. doi: 10.1172/JCI118951. J Clin Invest. 1996. PMID: 8833906 Free PMC article.

3

Isoform 1c of sterol regulatory element binding protein is less active than isoform 1a in livers of transgenic mice and in cultured cells.

Shimano H, Horton JD, Shimomura I, Hammer RE, Brown MS, Goldstein JL. Shimano H, et al. J Clin Invest. 1997 Mar 1;99(5):846-54. doi: 10.1172/JCI119248. J Clin Invest. 1997. PMID: 9062341 Free PMC article.

4

Elevated levels of SREBP-2 and cholesterol synthesis in livers of mice homozygous for a targeted disruption of the SREBP-1 gene.

Shimano H, Shimomura I, Hammer RE, Herz J, Goldstein JL, Brown MS, Horton JD. Shimano H, et al. J Clin Invest. 1997 Oct 15;100(8):2115-24. doi: 10.1172/JCI119746. J Clin Invest. 1997. PMID: 9329978 Free PMC article.

5

Cholesterol feeding reduces nuclear forms of sterol regulatory element binding proteins in hamster liver.

Shimomura I, Bashmakov Y, Shimano H, Horton JD, Goldstein JL, Brown MS. Shimomura I, et al. Among authors: shimano h. Proc Natl Acad Sci U S A. 1997 Nov 11;94(23):12354-9. doi: 10.1073/pnas.94.23.12354. Proc Natl Acad Sci U S A. 1997. PMID: 9356453 Free PMC article.

6

Regulation of sterol regulatory element binding proteins in livers of fasted and refed mice.

Horton JD, Bashmakov Y, Shimomura I, Shimano H. Horton JD, et al. Among authors: shimano h. Proc Natl Acad Sci U S A. 1998 May 26;95(11):5987-92. doi: 10.1073/pnas.95.11.5987. Proc Natl Acad Sci U S A. 1998. PMID: 9600904 Free PMC article.

7

Activation of cholesterol synthesis in preference to fatty acid synthesis in liver and adipose tissue of transgenic mice overproducing sterol regulatory element-binding protein-2.

Horton JD, Shimomura I, Brown MS, Hammer RE, Goldstein JL, Shimano H. Horton JD, et al. Among authors: shimano h. J Clin Invest. 1998 Jun 1;101(11):2331-9. doi: 10.1172/JCI2961. J Clin Invest. 1998. PMID: 9616204 Free PMC article.

8

Nuclear sterol regulatory element-binding proteins activate genes responsible for the entire program of unsaturated fatty acid biosynthesis in transgenic mouse liver.

Shimomura I, Shimano H, Korn BS, Bashmakov Y, Horton JD. Shimomura I, et al. Among authors: shimano h. J Biol Chem. 1998 Dec 25;273(52):35299-306. doi: 10.1074/jbc.273.52.35299. J Biol Chem. 1998. PMID: 9857071 Free article.

9

Disruption of LDL receptor gene in transgenic SREBP-1a mice unmasks hyperlipidemia resulting from production of lipid-rich VLDL.

Horton JD, Shimano H, Hamilton RL, Brown MS, Goldstein JL. Horton JD, et al. Among authors: shimano h. J Clin Invest. 1999 Apr;103(7):1067-76. doi: 10.1172/JCI6246. J Clin Invest. 1999. PMID: 10194480 Free PMC article.

10

PKClambda in liver mediates insulin-induced SREBP-1c expression and determines both hepatic lipid content and overall insulin sensitivity.

Matsumoto M, Ogawa W, Akimoto K, Inoue H, Miyake K, Furukawa K, Hayashi Y, Iguchi H, Matsuki Y, Hiramatsu R, Shimano H, Yamada N, Ohno S, Kasuga M, Noda T. Matsumoto M, et al. Among authors: shimano h. J Clin Invest. 2003 Sep;112(6):935-44. doi: 10.1172/JCI18816. J Clin Invest. 2003. PMID: 12975478 Free PMC article.

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