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A secreted PTEN phosphatase that enters cells to alter signaling and survival.
Hopkins BD, Fine B, Steinbach N, Dendy M, Rapp Z, Shaw J, Pappas K, Yu JS, Hodakoski C, Mense S, Klein J, Pegno S, Sulis ML, Goldstein H, Amendolara B, Lei L, Maurer M, Bruce J, Canoll P, Hibshoosh H, Parsons R. Hopkins BD, et al. Among authors: hibshoosh h. Science. 2013 Jul 26;341(6144):399-402. doi: 10.1126/science.1234907. Epub 2013 Jun 6. Science. 2013. PMID: 23744781 Free PMC article.
PTEN and NEDD4 in Human Breast Carcinoma.
Chen Y, van de Vijver MJ, Hibshoosh H, Parsons R, Saal LH. Chen Y, et al. Among authors: hibshoosh h. Pathol Oncol Res. 2016 Jan;22(1):41-7. doi: 10.1007/s12253-015-9971-2. Epub 2015 Aug 15. Pathol Oncol Res. 2016. PMID: 26276352 Free PMC article.
PCDH8, the human homolog of PAPC, is a candidate tumor suppressor of breast cancer.
Yu JS, Koujak S, Nagase S, Li CM, Su T, Wang X, Keniry M, Memeo L, Rojtman A, Mansukhani M, Hibshoosh H, Tycko B, Parsons R. Yu JS, et al. Among authors: hibshoosh h. Oncogene. 2008 Aug 7;27(34):4657-65. doi: 10.1038/onc.2008.101. Epub 2008 Apr 14. Oncogene. 2008. PMID: 18408767 Free PMC article.
Lack of PTEN sequesters CHK1 and initiates genetic instability.
Puc J, Keniry M, Li HS, Pandita TK, Choudhury AD, Memeo L, Mansukhani M, Murty VV, Gaciong Z, Meek SE, Piwnica-Worms H, Hibshoosh H, Parsons R. Puc J, et al. Among authors: hibshoosh h. Cancer Cell. 2005 Feb;7(2):193-204. doi: 10.1016/j.ccr.2005.01.009. Cancer Cell. 2005. PMID: 15710331 Free article.
Recurrent gross mutations of the PTEN tumor suppressor gene in breast cancers with deficient DSB repair.
Saal LH, Gruvberger-Saal SK, Persson C, Lövgren K, Jumppanen M, Staaf J, Jönsson G, Pires MM, Maurer M, Holm K, Koujak S, Subramaniyam S, Vallon-Christersson J, Olsson H, Su T, Memeo L, Ludwig T, Ethier SP, Krogh M, Szabolcs M, Murty VV, Isola J, Hibshoosh H, Parsons R, Borg A. Saal LH, et al. Among authors: hibshoosh h. Nat Genet. 2008 Jan;40(1):102-7. doi: 10.1038/ng.2007.39. Epub 2007 Dec 9. Nat Genet. 2008. PMID: 18066063 Free PMC article.
198 results