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Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130.
Nicholson SE, De Souza D, Fabri LJ, Corbin J, Willson TA, Zhang JG, Silva A, Asimakis M, Farley A, Nash AD, Metcalf D, Hilton DJ, Nicola NA, Baca M. Nicholson SE, et al. Among authors: silva a. Proc Natl Acad Sci U S A. 2000 Jun 6;97(12):6493-8. doi: 10.1073/pnas.100135197. Proc Natl Acad Sci U S A. 2000. PMID: 10829066 Free PMC article.
Suppressor of cytokine signaling (SOCS)-5 is a potential negative regulator of epidermal growth factor signaling.
Nicholson SE, Metcalf D, Sprigg NS, Columbus R, Walker F, Silva A, Cary D, Willson TA, Zhang JG, Hilton DJ, Alexander WS, Nicola NA. Nicholson SE, et al. Among authors: silva a. Proc Natl Acad Sci U S A. 2005 Feb 15;102(7):2328-33. doi: 10.1073/pnas.0409675102. Epub 2005 Feb 3. Proc Natl Acad Sci U S A. 2005. PMID: 15695332 Free PMC article.
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