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Sites important for PLCbeta2 activation by the G protein betagamma subunit map to the sides of the beta propeller structure.
Panchenko MP, Saxena K, Li Y, Charnecki S, Sternweis PM, Smith TF, Gilman AG, Kozasa T, Neer EJ. Panchenko MP, et al. Among authors: li y. J Biol Chem. 1998 Oct 23;273(43):28298-304. doi: 10.1074/jbc.273.43.28298. J Biol Chem. 1998. PMID: 9774453 Free article.
We have previously shown that sites for activation of PLCbeta2, PLCbeta3, and adenylyl cyclase II overlap on the "top" surface of the propeller, where Galpha also binds (Li, Y., Sternweis, P. M., Charnecki, S., Smith, T. F., Gilman, A. G., Neer, E. J., and Kozasa, T …
We have previously shown that sites for activation of PLCbeta2, PLCbeta3, and adenylyl cyclase II overlap on the "top" surface of the propel …
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