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Page 1
Alanine scanning mutagenesis of insulin.
Kristensen C, Kjeldsen T, Wiberg FC, Schäffer L, Hach M, Havelund S, Bass J, Steiner DF, Andersen AS. Kristensen C, et al. Among authors: kjeldsen t. J Biol Chem. 1997 May 16;272(20):12978-83. doi: 10.1074/jbc.272.20.12978. J Biol Chem. 1997. PMID: 9148904 Free article.
Identification of determinants that confer ligand specificity on the insulin receptor.
Andersen AS, Kjeldsen T, Wiberg FC, Vissing H, Schäffer L, Rasmussen JS, De Meyts P, Møller NP. Andersen AS, et al. Among authors: kjeldsen t. J Biol Chem. 1992 Jul 5;267(19):13681-6. J Biol Chem. 1992. PMID: 1320025 Free article.
We have previously shown, using truncated soluble recombinant receptors, that substituting the 62 N-terminal amino acids of the alpha subunit from the insulin-like growth factor I receptor (IGFIR) with the corresponding 68 amino acids from the insulin receptor (IR) results in a c …
We have previously shown, using truncated soluble recombinant receptors, that substituting the 62 N-terminal amino acids of the alpha subuni …
Chimeric receptors indicate that phenylalanine 39 is a major contributor to insulin specificity of the insulin receptor.
Kjeldsen T, Wiberg FC, Andersen AS. Kjeldsen T, et al. J Biol Chem. 1994 Dec 30;269(52):32942-6. J Biol Chem. 1994. PMID: 7806523 Free article.
The exact nature of how the insulin molecule interacts with the insulin receptor is obscure although chimeric receptors have shown that the ligand specificity of the insulin receptor and the IGF-I receptor (i.e. the sequences that discriminate between insulin and insulin-like gro …
The exact nature of how the insulin molecule interacts with the insulin receptor is obscure although chimeric receptors have shown that the …
106 results