O'Rahilly S - Search Results

1

Congenital leptin deficiency is associated with severe early-onset obesity in humans.

Montague CT, Farooqi IS, Whitehead JP, Soos MA, Rau H, Wareham NJ, Sewter CP, Digby JE, Mohammed SN, Hurst JA, Cheetham CH, Earley AR, Barnett AH, Prins JB, O'Rahilly S. Montague CT, et al. Nature. 1997 Jun 26;387(6636):903-8. doi: 10.1038/43185. Nature. 1997. PMID: 9202122

2

Monogenic obesity in humans.

Farooqi IS, O'Rahilly S. Farooqi IS, et al. Annu Rev Med. 2005;56:443-58. doi: 10.1146/annurev.med.56.062904.144924. Annu Rev Med. 2005. PMID: 15660521 Review.

3

Depot- and sex-specific differences in human leptin mRNA expression: implications for the control of regional fat distribution.

Montague CT, Prins JB, Sanders L, Digby JE, O'Rahilly S. Montague CT, et al. Diabetes. 1997 Mar;46(3):342-7. doi: 10.2337/diab.46.3.342. Diabetes. 1997. PMID: 9032087

4

Obesity and impaired prohormone processing associated with mutations in the human prohormone convertase 1 gene.

Jackson RS, Creemers JW, Ohagi S, Raffin-Sanson ML, Sanders L, Montague CT, Hutton JC, O'Rahilly S. Jackson RS, et al. Nat Genet. 1997 Jul;16(3):303-6. doi: 10.1038/ng0797-303. Nat Genet. 1997. PMID: 9207799

5

Truncated human leptin (delta133) associated with extreme obesity undergoes proteasomal degradation after defective intracellular transport.

Rau H, Reaves BJ, O'Rahilly S, Whitehead JP. Rau H, et al. Endocrinology. 1999 Apr;140(4):1718-23. doi: 10.1210/endo.140.4.6670. Endocrinology. 1999. PMID: 10098508

6

Recent advances in the genetics of severe childhood obesity.

Farooqi IS, O'Rahilly S. Farooqi IS, et al. Arch Dis Child. 2000 Jul;83(1):31-4. doi: 10.1136/adc.83.1.31. Arch Dis Child. 2000. PMID: 10868996 Free PMC article. Review.

7

Partial leptin deficiency and human adiposity.

Farooqi IS, Keogh JM, Kamath S, Jones S, Gibson WT, Trussell R, Jebb SA, Lip GY, O'Rahilly S. Farooqi IS, et al. Nature. 2001 Nov 1;414(6859):34-5. doi: 10.1038/35102112. Nature. 2001. PMID: 11689931

8

Digenic inheritance of severe insulin resistance in a human pedigree.

Savage DB, Agostini M, Barroso I, Gurnell M, Luan J, Meirhaeghe A, Harding AH, Ihrke G, Rajanayagam O, Soos MA, George S, Berger D, Thomas EL, Bell JD, Meeran K, Ross RJ, Vidal-Puig A, Wareham NJ, O'Rahilly S, Chatterjee VK, Schafer AJ. Savage DB, et al. Nat Genet. 2002 Aug;31(4):379-84. doi: 10.1038/ng926. Epub 2002 Jul 15. Nat Genet. 2002. PMID: 12118251

9

A missense mutation disrupting a dibasic prohormone processing site in pro-opiomelanocortin (POMC) increases susceptibility to early-onset obesity through a novel molecular mechanism.

Challis BG, Pritchard LE, Creemers JW, Delplanque J, Keogh JM, Luan J, Wareham NJ, Yeo GS, Bhattacharyya S, Froguel P, White A, Farooqi IS, O'Rahilly S. Challis BG, et al. Hum Mol Genet. 2002 Aug 15;11(17):1997-2004. doi: 10.1093/hmg/11.17.1997. Hum Mol Genet. 2002. PMID: 12165561

10

Beneficial effects of leptin on obesity, T cell hyporesponsiveness, and neuroendocrine/metabolic dysfunction of human congenital leptin deficiency.

Farooqi IS, Matarese G, Lord GM, Keogh JM, Lawrence E, Agwu C, Sanna V, Jebb SA, Perna F, Fontana S, Lechler RI, DePaoli AM, O'Rahilly S. Farooqi IS, et al. J Clin Invest. 2002 Oct;110(8):1093-103. doi: 10.1172/JCI15693. J Clin Invest. 2002. PMID: 12393845 Free PMC article.

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