Stean TO - Search Results

1

Characterization of the binding of [3H]-SB-204269, a radiolabelled form of the new anticonvulsant SB-204269, to a novel binding site in rat brain membranes.

Herdon HJ, Jerman JC, Stean TO, Middlemiss DN, Chan WN, Vong AK, Evans JM, Thompson M, Upton N. Herdon HJ, et al. Among authors: stean to. Br J Pharmacol. 1997 Aug;121(8):1687-91. doi: 10.1038/sj.bjp.0701331. Br J Pharmacol. 1997. PMID: 9283704 Free PMC article.

2

The novel anticonvulsant SB 204269 binds to a stereospecific site in the mouse brain.

Herdon H, Jerman J, Stean T, Chan W, Middlemiss D, Upton N. Herdon H, et al. Eur J Pharmacol. 1996 Oct 31;314(3):R7-8. doi: 10.1016/s0014-2999(96)00737-6. Eur J Pharmacol. 1996. PMID: 8957267

3

Characterization of SB-269970-A, a selective 5-HT(7) receptor antagonist.

Hagan JJ, Price GW, Jeffrey P, Deeks NJ, Stean T, Piper D, Smith MI, Upton N, Medhurst AD, Middlemiss DN, Riley GJ, Lovell PJ, Bromidge SM, Thomas DR. Hagan JJ, et al. Br J Pharmacol. 2000 Jun;130(3):539-48. doi: 10.1038/sj.bjp.0703357. Br J Pharmacol. 2000. PMID: 10821781 Free PMC article.

4

Characterization of SB-271046: a potent, selective and orally active 5-HT(6) receptor antagonist.

Routledge C, Bromidge SM, Moss SF, Price GW, Hirst W, Newman H, Riley G, Gager T, Stean T, Upton N, Clarke SE, Brown AM, Middlemiss DN. Routledge C, et al. Br J Pharmacol. 2000 Aug;130(7):1606-12. doi: 10.1038/sj.bjp.0703457. Br J Pharmacol. 2000. PMID: 10928964 Free PMC article.

5

Synthesis of novel trans-4-(substituted-benzamido)-3,4-dihydro-2H-benzo[b]-pyran-3-ol derivatives as potential anticonvulsant agents with a distinctive binding profile.

Chan WN, Evans JM, Hadley MS, Herdon HJ, Jerman JC, Morgan HK, Stean TO, Thompson M, Upton N, Vong AK. Chan WN, et al. Among authors: stean to. J Med Chem. 1996 Nov 8;39(23):4537-9. doi: 10.1021/jm960535w. J Med Chem. 1996. PMID: 8917640 No abstract available.

6

Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures.

Upton N, Blackburn TP, Campbell CA, Cooper D, Evans ML, Herdon HJ, King PD, Ray AM, Stean TO, Chan WN, Evans JM, Thompson M. Upton N, et al. Among authors: stean to. Br J Pharmacol. 1997 Aug;121(8):1679-86. doi: 10.1038/sj.bjp.0701330. Br J Pharmacol. 1997. PMID: 9283703 Free PMC article.

7

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity.

Chan WN, Hadley MS, Harling JD, Herdon HJ, Jerman JC, Orlek BS, Stean TO, Thompson M, Upton N, Ward RW. Chan WN, et al. Among authors: stean to. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2903-6. doi: 10.1016/s0960-894x(98)00523-x. Bioorg Med Chem Lett. 1998. PMID: 9873645

8

Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent.

Chan WN, Evans JM, Hadley MS, Herdon HJ, Jerman JC, Parsons AA, Read SJ, Stean TO, Thompson M, Upton N. Chan WN, et al. Among authors: stean to. Bioorg Med Chem Lett. 1999 Jan 18;9(2):285-90. doi: 10.1016/s0960-894x(98)00728-8. Bioorg Med Chem Lett. 1999. PMID: 10021946

9

Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides.

Chan WN, Hadley MS, Harling JD, Herdon HJ, Orlek BS, Riley GJ, Stead RE, Stean TO, Thompson M, Upton N, Ward RW. Chan WN, et al. Among authors: stean to. Bioorg Med Chem. 2000 Aug;8(8):2085-94. doi: 10.1016/s0968-0896(00)00149-8. Bioorg Med Chem. 2000. PMID: 11003154

10

SB-656104-A, a novel selective 5-HT7 receptor antagonist, modulates REM sleep in rats.

Thomas DR, Melotto S, Massagrande M, Gribble AD, Jeffrey P, Stevens AJ, Deeks NJ, Eddershaw PJ, Fenwick SH, Riley G, Stean T, Scott CM, Hill MJ, Middlemiss DN, Hagan JJ, Price GW, Forbes IT. Thomas DR, et al. Br J Pharmacol. 2003 Jun;139(4):705-14. doi: 10.1038/sj.bjp.0705290. Br J Pharmacol. 2003. PMID: 12812993 Free PMC article.

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