Thompson M - Search Results

1

Characterization of the binding of [3H]-SB-204269, a radiolabelled form of the new anticonvulsant SB-204269, to a novel binding site in rat brain membranes.

Herdon HJ, Jerman JC, Stean TO, Middlemiss DN, Chan WN, Vong AK, Evans JM, Thompson M, Upton N. Herdon HJ, et al. Among authors: thompson m. Br J Pharmacol. 1997 Aug;121(8):1687-91. doi: 10.1038/sj.bjp.0701331. Br J Pharmacol. 1997. PMID: 9283704 Free PMC article.

2

Synthesis of novel trans-4-(substituted-benzamido)-3,4-dihydro-2H-benzo[b]-pyran-3-ol derivatives as potential anticonvulsant agents with a distinctive binding profile.

Chan WN, Evans JM, Hadley MS, Herdon HJ, Jerman JC, Morgan HK, Stean TO, Thompson M, Upton N, Vong AK. Chan WN, et al. Among authors: thompson m. J Med Chem. 1996 Nov 8;39(23):4537-9. doi: 10.1021/jm960535w. J Med Chem. 1996. PMID: 8917640 No abstract available.

3

Profile of SB-204269, a mechanistically novel anticonvulsant drug, in rat models of focal and generalized epileptic seizures.

Upton N, Blackburn TP, Campbell CA, Cooper D, Evans ML, Herdon HJ, King PD, Ray AM, Stean TO, Chan WN, Evans JM, Thompson M. Upton N, et al. Among authors: thompson m. Br J Pharmacol. 1997 Aug;121(8):1679-86. doi: 10.1038/sj.bjp.0701330. Br J Pharmacol. 1997. PMID: 9283703 Free PMC article.

4

Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity.

Chan WN, Hadley MS, Harling JD, Herdon HJ, Jerman JC, Orlek BS, Stean TO, Thompson M, Upton N, Ward RW. Chan WN, et al. Among authors: thompson m. Bioorg Med Chem Lett. 1998 Oct 20;8(20):2903-6. doi: 10.1016/s0960-894x(98)00523-x. Bioorg Med Chem Lett. 1998. PMID: 9873645

5

Identification of (-)-cis-6-acetyl-4S-(3-chloro-4-fluoro-benzoylamino)- 3,4-dihydro-2,2-dimethyl-2H-benzo[b]pyran-3S-ol as a potential antimigraine agent.

Chan WN, Evans JM, Hadley MS, Herdon HJ, Jerman JC, Parsons AA, Read SJ, Stean TO, Thompson M, Upton N. Chan WN, et al. Among authors: thompson m. Bioorg Med Chem Lett. 1999 Jan 18;9(2):285-90. doi: 10.1016/s0960-894x(98)00728-8. Bioorg Med Chem Lett. 1999. PMID: 10021946

6

Evaluation of a series of anticonvulsant 1,2,3,4-tetrahydroisoquinolinyl-benzamides.

Chan WN, Hadley MS, Harling JD, Herdon HJ, Orlek BS, Riley GJ, Stead RE, Stean TO, Thompson M, Upton N, Ward RW. Chan WN, et al. Among authors: thompson m. Bioorg Med Chem. 2000 Aug;8(8):2085-94. doi: 10.1016/s0968-0896(00)00149-8. Bioorg Med Chem. 2000. PMID: 11003154

7

Tonabersat (SB-220453) a novel benzopyran with anticonvulsant properties attenuates trigeminal nerve-induced neurovascular reflexes.

Parsons AA, Bingham S, Raval P, Read S, Thompson M, Upton N. Parsons AA, et al. Among authors: thompson m. Br J Pharmacol. 2001 Apr;132(7):1549-57. doi: 10.1038/sj.bjp.0703932. Br J Pharmacol. 2001. PMID: 11264249 Free PMC article.

8

Benzo[b]pyranols and related novel antiepileptic agents.

Upton N, Thompson M. Upton N, et al. Among authors: thompson m. Prog Med Chem. 2000;37:177-200. doi: 10.1016/s0079-6468(08)70060-2. Prog Med Chem. 2000. PMID: 10845250 Review. No abstract available.

9

Repetitive cortical spreading depression in a gyrencephalic feline brain: inhibition by the novel benzoylamino-benzopyran SB-220453.

Smith MI, Read SJ, Chan WN, Thompson M, Hunter AJ, Upton N, Parsons AA. Smith MI, et al. Among authors: thompson m. Cephalalgia. 2000 Jul;20(6):546-53. doi: 10.1046/j.1468-2982.2000.00092.x. Cephalalgia. 2000. PMID: 11075837

10

The design of 8,8-dimethyl[1,6]naphthyridines as potential anticonvulsant agents.

Austin NE, Hadley MS, Harling JD, Harrington FP, Macdonald GJ, Mitchell DJ, Riley GJ, Stean TO, Stemp G, Stratton SC, Thompson M, Upton N. Austin NE, et al. Among authors: thompson m. Bioorg Med Chem Lett. 2003 May 19;13(10):1627-9. doi: 10.1016/s0960-894x(03)00288-9. Bioorg Med Chem Lett. 2003. PMID: 12729628

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