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Implications for isoform-selective inhibitor design derived from the binding mode of bulky isothioureas to the heme domain of endothelial nitric-oxide synthase.
Raman CS, Li H, Martásek P, Babu BR, Griffith OW, Masters BS, Poulos TL. Raman CS, et al. Among authors: martasek p. J Biol Chem. 2001 Jul 13;276(28):26486-91. doi: 10.1074/jbc.M102255200. Epub 2001 Apr 30. J Biol Chem. 2001. PMID: 11331290 Free article.
Isothioureas are potent NOS inhibitors, and the structures of the endothelial NOS heme domain complexed with isothioureas bearing small S-alkyl substituents have been determined (Li, H., Raman, C.S., Martasek, P., Kral, V., Masters, B.S.S., and Poulos, T.L. (2000) J …
Isothioureas are potent NOS inhibitors, and the structures of the endothelial NOS heme domain complexed with isothioureas bearing small S-al …
Oxygen metabolism by neuronal nitric-oxide synthase.
Gao YT, Panda SP, Roman LJ, Martásek P, Ishimura Y, Masters BS. Gao YT, et al. Among authors: martasek p. J Biol Chem. 2007 Mar 16;282(11):7921-9. doi: 10.1074/jbc.M609814200. Epub 2007 Jan 17. J Biol Chem. 2007. PMID: 17229730 Free article.
Oxygen metabolism by endothelial nitric-oxide synthase.
Gao YT, Roman LJ, Martásek P, Panda SP, Ishimura Y, Masters BSS. Gao YT, et al. Among authors: martasek p. J Biol Chem. 2007 Sep 28;282(39):28557-28565. doi: 10.1074/jbc.M704890200. Epub 2007 Aug 13. J Biol Chem. 2007. PMID: 17698846 Free article.
N(omega)-Nitroarginine-containing dipeptide amides. Potent and highly selective inhibitors of neuronal nitric oxide synthase.
Huang H, Martasek P, Roman LJ, Masters BS, Silverman RB. Huang H, et al. Among authors: martasek p. J Med Chem. 1999 Aug 12;42(16):3147-53. doi: 10.1021/jm990111c. J Med Chem. 1999. PMID: 10447959
Recently, we reported the dipeptide methyl ester, D-Phe-D-Arg(NO)()2-OMe (19), as a modest inhibitor of nNOS (K(i) = 2 microM), but with selectivity over iNOS as high as 1800-fold (Silverman, R. B.; Huang, H.; Marletta, M. A.; Martasek, P. J. Med. Chem. 1997, 40, 28 …
Recently, we reported the dipeptide methyl ester, D-Phe-D-Arg(NO)()2-OMe (19), as a modest inhibitor of nNOS (K(i) = 2 microM), but with sel …
275 results