Cane DE - Search Results

1

Molecular recognition of diketide substrates by a beta-ketoacyl-acyl carrier protein synthase domain within a bimodular polyketide synthase.

Chuck JA, McPherson M, Huang H, Jacobsen JR, Khosla C, Cane DE. Chuck JA, et al. Among authors: cane de. Chem Biol. 1997 Oct;4(10):757-66. doi: 10.1016/s1074-5521(97)90314-8. Chem Biol. 1997. PMID: 9375254

2

Recognition of acyl carrier proteins by ketoreductases in assembly line polyketide synthases.

Ostrowski MP, Cane DE, Khosla C. Ostrowski MP, et al. Among authors: cane de. J Antibiot (Tokyo). 2016 Jul;69(7):507-10. doi: 10.1038/ja.2016.41. Epub 2016 Apr 27. J Antibiot (Tokyo). 2016. PMID: 27118242 Free PMC article.

3

Biochemical analysis of the substrate specificity of the beta-ketoacyl-acyl carrier protein synthase domain of module 2 of the erythromycin polyketide synthase.

Wu J, Kinoshita K, Khosla C, Cane DE. Wu J, et al. Among authors: cane de. Biochemistry. 2004 Dec 28;43(51):16301-10. doi: 10.1021/bi048147g. Biochemistry. 2004. PMID: 15610024

4

Modular polyketide synthases: Investigating intermodular communication using 6 deoxyerythronolide B synthase module 2.

Moffet DA, Khosla C, Cane DE. Moffet DA, et al. Among authors: cane de. Bioorg Med Chem Lett. 2006 Jan 1;16(1):213-6. doi: 10.1016/j.bmcl.2005.09.017. Epub 2005 Oct 5. Bioorg Med Chem Lett. 2006. PMID: 16213712

5

Precursor-directed biosynthesis: biochemical basis of the remarkable selectivity of the erythromycin polyketide synthase toward unsaturated triketides.

Cane DE, Kudo F, Kinoshita K, Khosla C. Cane DE, et al. Chem Biol. 2002 Jan;9(1):131-42. doi: 10.1016/s1074-5521(02)00089-3. Chem Biol. 2002. PMID: 11841945

6

6-deoxyerythronolide B synthase 1 is specifically acylated by a diketide intermediate at the beta-ketoacyl-acyl carrier protein synthase domain of module 2.

Tsukamoto N, Chuck JA, Luo G, Kao CM, Khosla C, Cane DE. Tsukamoto N, et al. Among authors: cane de. Biochemistry. 1996 Dec 3;35(48):15244-8. doi: 10.1021/bi961972f. Biochemistry. 1996. PMID: 8952473

7

Harnessing the biosynthetic code: combinations, permutations, and mutations.

Cane DE, Walsh CT, Khosla C. Cane DE, et al. Science. 1998 Oct 2;282(5386):63-8. doi: 10.1126/science.282.5386.63. Science. 1998. PMID: 9756477 Review.

8

Mechanism and specificity of the terminal thioesterase domain from the erythromycin polyketide synthase.

Gokhale RS, Hunziker D, Cane DE, Khosla C. Gokhale RS, et al. Among authors: cane de. Chem Biol. 1999 Feb;6(2):117-25. doi: 10.1016/S1074-5521(99)80008-8. Chem Biol. 1999. PMID: 10021418

9

Erythromycin biosynthesis. The 4-pro-S hydride of NADPH is utilized for ketoreduction by both module 5 and module 6 of the 6-deoxyerythronolide B synthase.

Yin Y, Gokhale R, Khosla C, Cane DE. Yin Y, et al. Among authors: cane de. Bioorg Med Chem Lett. 2001 Jun 18;11(12):1477-9. doi: 10.1016/s0960-894x(00)00529-1. Bioorg Med Chem Lett. 2001. PMID: 11412964

10

Erythromycin biosynthesis: exploiting the catalytic versatility of the modular polyketide synthase.

Luo G, Pieper R, Rosa A, Khosla C, Cane DE. Luo G, et al. Among authors: cane de. Bioorg Med Chem. 1996 Jul;4(7):995-9. doi: 10.1016/0968-0896(96)00096-x. Bioorg Med Chem. 1996. PMID: 8831969

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