Smyth MS - Search Results

1

Fibrinogen receptor (GPIIb-IIIa) antagonists derived from 5,6-bicyclic templates. Amidinoindoles, amidinoindazoles, and amidinobenzofurans containing the N-alpha-sulfonamide carboxylic acid function as potent platelet aggregation inhibitors.

Su T, Naughton MA, Smyth MS, Rose JW, Arfsten AE, McCowan JR, Jakubowski JA, Wyss VL, Ruterbories KJ, Sall DJ, Scarborough RM. Su T, et al. Among authors: smyth ms. J Med Chem. 1997 Dec 19;40(26):4308-18. doi: 10.1021/jm9704863. J Med Chem. 1997. PMID: 9435900

2

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 3: synthesis and SAR of potent and specific 2,8-diazaspiro[4.5]decanes.

Mehrotra MM, Heath JA, Rose JW, Smyth MS, Seroogy J, Volkots DL, Ruhter G, Schotten T, Alaimo L, Park G, Pandey A, Scarborough RM. Mehrotra MM, et al. Among authors: smyth ms. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1103-7. doi: 10.1016/s0960-894x(02)00095-1. Bioorg Med Chem Lett. 2002. PMID: 11909727

3

Discovery of novel 2,8-diazaspiro[4.5]decanes as orally active glycoprotein IIb-IIIa antagonists.

Mehrotra MM, Heath JA, Smyth MS, Pandey A, Rose JW, Seroogy JM, Volkots DL, Nannizzi-Alaimo L, Park GL, Lambing JL, Hollenbach SJ, Scarborough RM. Mehrotra MM, et al. Among authors: smyth ms. J Med Chem. 2004 Apr 8;47(8):2037-61. doi: 10.1021/jm030354b. J Med Chem. 2004. PMID: 15056002

4

Use of conformationally restricted benzamidines as arginine surrogates in the design of platelet GPIIb-IIIa receptor antagonists.

Sall DJ, Arfsten AE, Bastian JA, Denney ML, Harms CS, McCowan JR, Morin JM Jr, Rose JW, Scarborough RM, Smyth MS, Um SL, Utterback BG, Vasileff RT, Wikel JH, Wyss VL, Jakubowski JA. Sall DJ, et al. Among authors: smyth ms. J Med Chem. 1997 Aug 29;40(18):2843-57. doi: 10.1021/jm970020k. J Med Chem. 1997. PMID: 9288166

5

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 1: design of potent and specific 3,9-diazaspiro[5.5]undecanes.

Smyth MS, Rose J, Mehrotra MM, Heath J, Ruhter G, Schotten T, Seroogy J, Volkots D, Pandey A, Scarborough RM. Smyth MS, et al. Bioorg Med Chem Lett. 2001 May 21;11(10):1289-92. doi: 10.1016/s0960-894x(01)00215-3. Bioorg Med Chem Lett. 2001. PMID: 11392539

6

Spirocyclic nonpeptide glycoprotein IIb-IIIa antagonists. Part 2: design of potent antagonists containing the 3-azaspiro[5.5]undecanes.

Pandey A, Seroogy J, Volkots D, Smyth MS, Rose J, Mehrotra MM, Heath J, Ruhter G, Schotten T, Scarborough RM. Pandey A, et al. Among authors: smyth ms. Bioorg Med Chem Lett. 2001 May 21;11(10):1293-6. doi: 10.1016/s0960-894x(01)00216-5. Bioorg Med Chem Lett. 2001. PMID: 11392540

7

Antitumor activity of PR-171, a novel irreversible inhibitor of the proteasome.

Demo SD, Kirk CJ, Aujay MA, Buchholz TJ, Dajee M, Ho MN, Jiang J, Laidig GJ, Lewis ER, Parlati F, Shenk KD, Smyth MS, Sun CM, Vallone MK, Woo TM, Molineaux CJ, Bennett MK. Demo SD, et al. Among authors: smyth ms. Cancer Res. 2007 Jul 1;67(13):6383-91. doi: 10.1158/0008-5472.CAN-06-4086. Cancer Res. 2007. PMID: 17616698

8

Picornavirus uncoating.

Smyth MS, Martin JH. Smyth MS, et al. Mol Pathol. 2002 Aug;55(4):214-9. doi: 10.1136/mp.55.4.214. Mol Pathol. 2002. PMID: 12147709 Free PMC article. Review.

9

Structural, biochemical and electrostatic basis of serotype specificity in bovine enteroviruses.

Smyth MS, Martin JH. Smyth MS, et al. Arch Virol. 2001;146(2):347-55. doi: 10.1007/s007050170179. Arch Virol. 2001. PMID: 11315642

10

Conformational changes during proteolytic processing of a picornavirus capsid proteins.

Smyth MS, Trudgett A, Martin JH, Hoey EM, Martin SJ. Smyth MS, et al. Arch Virol. 2000;145(7):1473-9. doi: 10.1007/s007050070104. Arch Virol. 2000. PMID: 10963351

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