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Presenilin 2 deficiency causes a mild pulmonary phenotype and no changes in amyloid precursor protein processing but enhances the embryonic lethal phenotype of presenilin 1 deficiency.
Herreman A, Hartmann D, Annaert W, Saftig P, Craessaerts K, Serneels L, Umans L, Schrijvers V, Checler F, Vanderstichele H, Baekelandt V, Dressel R, Cupers P, Huylebroeck D, Zwijsen A, Van Leuven F, De Strooper B. Herreman A, et al. Among authors: vanderstichele h. Proc Natl Acad Sci U S A. 1999 Oct 12;96(21):11872-7. doi: 10.1073/pnas.96.21.11872. Proc Natl Acad Sci U S A. 1999. PMID: 10518543 Free PMC article.
Aging increased amyloid peptide and caused amyloid plaques in brain of old APP/V717I transgenic mice by a different mechanism than mutant presenilin1.
Dewachter I, Van Dorpe J, Smeijers L, Gilis M, Kuipéri C, Laenen I, Caluwaerts N, Moechars D, Checler F, Vanderstichele H, Van Leuven F. Dewachter I, et al. Among authors: vanderstichele h. J Neurosci. 2000 Sep 1;20(17):6452-8. doi: 10.1523/JNEUROSCI.20-17-06452.2000. J Neurosci. 2000. PMID: 10964951 Free PMC article.
Prominent cerebral amyloid angiopathy in transgenic mice overexpressing the london mutant of human APP in neurons.
Van Dorpe J, Smeijers L, Dewachter I, Nuyens D, Spittaels K, Van Den Haute C, Mercken M, Moechars D, Laenen I, Kuiperi C, Bruynseels K, Tesseur I, Loos R, Vanderstichele H, Checler F, Sciot R, Van Leuven F. Van Dorpe J, et al. Among authors: vanderstichele h. Am J Pathol. 2000 Oct;157(4):1283-98. doi: 10.1016/S0002-9440(10)64644-5. Am J Pathol. 2000. PMID: 11021833 Free PMC article.
Nonfibrillar diffuse amyloid deposition due to a gamma(42)-secretase site mutation points to an essential role for N-truncated A beta(42) in Alzheimer's disease.
Kumar-Singh S, De Jonghe C, Cruts M, Kleinert R, Wang R, Mercken M, De Strooper B, Vanderstichele H, Löfgren A, Vanderhoeven I, Backhovens H, Vanmechelen E, Kroisel PM, Van Broeckhoven C. Kumar-Singh S, et al. Among authors: vanderstichele h. Hum Mol Genet. 2000 Nov 1;9(18):2589-98. doi: 10.1093/hmg/9.18.2589. Hum Mol Genet. 2000. PMID: 11063718
Aberrant splicing in the presenilin-1 intron 4 mutation causes presenile Alzheimer's disease by increased Abeta42 secretion.
De Jonghe C, Cruts M, Rogaeva EA, Tysoe C, Singleton A, Vanderstichele H, Meschino W, Dermaut B, Vanderhoeven I, Backhovens H, Vanmechelen E, Morris CM, Hardy J, Rubinsztein DC, St George-Hyslop PH, Van Broeckhoven C. De Jonghe C, et al. Among authors: vanderstichele h. Hum Mol Genet. 1999 Aug;8(8):1529-40. doi: 10.1093/hmg/8.8.1529. Hum Mol Genet. 1999. PMID: 10401002
The cerebrospinal fluid levels of tau, growth-associated protein-43 and soluble amyloid precursor protein correlate in Alzheimer's disease, reflecting a common pathophysiological process.
Sjögren M, Davidsson P, Gottfries J, Vanderstichele H, Edman A, Vanmechelen E, Wallin A, Blennow K. Sjögren M, et al. Among authors: vanderstichele h. Dement Geriatr Cogn Disord. 2001 Jul-Aug;12(4):257-64. doi: 10.1159/000051268. Dement Geriatr Cogn Disord. 2001. PMID: 11351137
The effect of simvastatin treatment on the amyloid precursor protein and brain cholesterol metabolism in patients with Alzheimer's disease.
Hoglund K, Thelen KM, Syversen S, Sjogren M, von Bergmann K, Wallin A, Vanmechelen E, Vanderstichele H, Lutjohann D, Blennow K. Hoglund K, et al. Among authors: vanderstichele h. Dement Geriatr Cogn Disord. 2005;19(5-6):256-65. doi: 10.1159/000084550. Epub 2005 Mar 21. Dement Geriatr Cogn Disord. 2005. PMID: 15785028
159 results