Douglas KT - Search Results

1

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH. Chan C, et al. Among authors: douglas kt. J Med Chem. 1998 Jan 15;41(2):148-56. doi: 10.1021/jm960814j. J Med Chem. 1998. PMID: 9457238

2

Antitrypanosomal, antileishmanial, and antimalarial activities of quaternary arylalkylammonium 2-amino-4-chlorophenyl phenyl sulfides, a new class of trypanothione reductase inhibitor, and of N-acyl derivatives of 2-amino-4-chlorophenyl phenyl sulfide.

Parveen S, Khan MO, Austin SE, Croft SL, Yardley V, Rock P, Douglas KT. Parveen S, et al. Among authors: douglas kt. J Med Chem. 2005 Dec 15;48(25):8087-97. doi: 10.1021/jm050819t. J Med Chem. 2005. PMID: 16335933

3

Rationally designed selective inhibitors of trypanothione reductase. Phenothiazines and related tricyclics as lead structures.

Benson TJ, McKie JH, Garforth J, Borges A, Fairlamb AH, Douglas KT. Benson TJ, et al. Among authors: douglas kt. Biochem J. 1992 Aug 15;286 ( Pt 1)(Pt 1):9-11. doi: 10.1042/bj2860009. Biochem J. 1992. PMID: 1355650 Free PMC article.

4

Synthesis of N-benzyloxycarbonyl-L-cysteinylglycine 3-dimethylaminopropylamide disulfide: a cheap and convenient new assay for trypanothione reductase.

el-Waer A, Douglas KT, Smith K, Fairlamb AH. el-Waer A, et al. Among authors: douglas kt. Anal Biochem. 1991 Oct;198(1):212-6. doi: 10.1016/0003-2697(91)90531-w. Anal Biochem. 1991. PMID: 1789428

5

The glutamyl binding site of trypanothione reductase from Crithidia fasciculata: enzyme kinetic properties of gamma-glutamyl-modified substrate analogues.

el-Waer AF, Smith K, McKie JH, Benson T, Fairlamb AH, Douglas KT. el-Waer AF, et al. Among authors: douglas kt. Biochim Biophys Acta. 1993 Nov 10;1203(1):93-8. doi: 10.1016/0167-4838(93)90040-x. Biochim Biophys Acta. 1993. PMID: 8105896

6

Inhibitors of trypanothione reductase as potential antitrypanosomal drugs.

Chan C, Yin H, Garforth J, McKie JH, Jaouhari RA, Douglas KT, Fairlamb AH, Croft SL. Chan C, et al. Among authors: douglas kt. Biochem Soc Trans. 1995 Nov;23(4):511S. doi: 10.1042/bst023511s. Biochem Soc Trans. 1995. PMID: 8654696 No abstract available.

7

Rational design of selective ligands for trypanothione reductase from Trypanosoma cruzi. Structural effects on the inhibition by dibenzazepines based on imipramine.

Garforth J, Yin H, McKie JH, Douglas KT, Fairlamb AH. Garforth J, et al. Among authors: douglas kt. J Enzyme Inhib. 1997 Aug;12(3):161-73. doi: 10.3109/14756369709029312. J Enzyme Inhib. 1997. PMID: 9314113

8

Rational drug design approach for overcoming drug resistance: application to pyrimethamine resistance in malaria.

McKie JH, Douglas KT, Chan C, Roser SA, Yates R, Read M, Hyde JE, Dascombe MJ, Yuthavong Y, Sirawaraporn W. McKie JH, et al. Among authors: douglas kt. J Med Chem. 1998 Apr 23;41(9):1367-70. doi: 10.1021/jm970845u. J Med Chem. 1998. PMID: 9554869

9

Inhibitors of glutathione reductase as potential antimalarial drugs. Kinetic cooperativity and effect of dimethyl sulphoxide on inhibition kinetics.

Lüönd RM, McKie JH, Douglas KT, Dascombe MJ, Vale J. Lüönd RM, et al. Among authors: douglas kt. J Enzyme Inhib. 1998 Aug;13(5):327-45. doi: 10.3109/14756369809021479. J Enzyme Inhib. 1998. PMID: 9793837

10

Synthesis and enzymology of modified N-benzyloxycarbonyl-L-cysteinylglycyl-3,3-dimethylaminopropylamide++ + disulphides as alternative substrates for trypanothione reductase from Trypanosoma cruzi: Part 3.

Yuen CT, Garforth J, Besheya T, Jaouhari R, McKie JH, Fairlamb AH, Douglas KT. Yuen CT, et al. Among authors: douglas kt. Amino Acids. 1999;17(2):175-83. doi: 10.1007/BF01361880. Amino Acids. 1999. PMID: 10524275

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