Yardley V - Search Results

1

Phenothiazine inhibitors of trypanothione reductase as potential antitrypanosomal and antileishmanial drugs.

Chan C, Yin H, Garforth J, McKie JH, Jaouhari R, Speers P, Douglas KT, Rock PJ, Yardley V, Croft SL, Fairlamb AH. Chan C, et al. Among authors: yardley v. J Med Chem. 1998 Jan 15;41(2):148-56. doi: 10.1021/jm960814j. J Med Chem. 1998. PMID: 9457238

2

Synthesis and evaluation of 9,9-dimethylxanthene tricyclics against trypanothione reductase, Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani.

Chibale K, Visser M, Yardley V, Croft SL, Fairlamb AH. Chibale K, et al. Among authors: yardley v. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1147-50. doi: 10.1016/s0960-894x(00)00154-2. Bioorg Med Chem Lett. 2000. PMID: 10866368

3

Squalamine analogues as potential anti-trypanosomal and anti-leishmanial compounds.

Khabnadideh S, Tan CL, Croft SL, Kendrick H, Yardley V, Gilbert IH. Khabnadideh S, et al. Among authors: yardley v. Bioorg Med Chem Lett. 2000 Jun 5;10(11):1237-9. doi: 10.1016/s0960-894x(00)00196-7. Bioorg Med Chem Lett. 2000. PMID: 10866389

4

Use of an additional hydrophobic binding site, the Z site, in the rational drug design of a new class of stronger trypanothione reductase inhibitor, quaternary alkylammonium phenothiazines.

Khan MO, Austin SE, Chan C, Yin H, Marks D, Vaghjiani SN, Kendrick H, Yardley V, Croft SL, Douglas KT. Khan MO, et al. Among authors: yardley v. J Med Chem. 2000 Aug 10;43(16):3148-56. doi: 10.1021/jm000156+. J Med Chem. 2000. PMID: 10956223

5

QSAR study on the contribution of log P and E(s) to the in vitro antiprotozoal activity of glutathione derivatives.

Daunes S, D'Silva C, Kendrick H, Yardley V, Croft SL. Daunes S, et al. Among authors: yardley v. J Med Chem. 2001 Aug 30;44(18):2976-83. doi: 10.1021/jm000502n. J Med Chem. 2001. PMID: 11520206

6

Structure-activity relationships for the antileishmanial and antitrypanosomal activities of 1'-substituted 9-anilinoacridines.

Gamage SA, Figgitt DP, Wojcik SJ, Ralph RK, Ransijn A, Mauel J, Yardley V, Snowdon D, Croft SL, Denny WA. Gamage SA, et al. Among authors: yardley v. J Med Chem. 1997 Aug 1;40(16):2634-42. doi: 10.1021/jm970232h. J Med Chem. 1997. PMID: 9258370

7

Cytotoxicity of (2,2':6',2''-terpyridine)platinum(II) complexes to Leishmania donovani, Trypanosoma cruzi, and Trypanosoma brucei.

Lowe G, Droz AS, Vilaivan T, Weaver GW, Tweedale L, Pratt JM, Rock P, Yardley V, Croft SL. Lowe G, et al. Among authors: yardley v. J Med Chem. 1999 Mar 25;42(6):999-1006. doi: 10.1021/jm981074c. J Med Chem. 1999. PMID: 10090783

8

In vitro antitrypanosomal activity of Moringa stenopetala leaves and roots.

Mekonnen Y, Yardley V, Rock P, Croft S. Mekonnen Y, et al. Among authors: yardley v. Phytother Res. 1999 Sep;13(6):538-9. doi: 10.1002/(sici)1099-1573(199909)13:6<538::aid-ptr486>3.0.co;2-k. Phytother Res. 1999. PMID: 10479771

9

2- and 3-substituted 1,4-naphthoquinone derivatives as subversive substrates of trypanothione reductase and lipoamide dehydrogenase from Trypanosoma cruzi: synthesis and correlation between redox cycling activities and in vitro cytotoxicity.

Salmon-Chemin L, Buisine E, Yardley V, Kohler S, Debreu MA, Landry V, Sergheraert C, Croft SL, Krauth-Siegel RL, Davioud-Charvet E. Salmon-Chemin L, et al. Among authors: yardley v. J Med Chem. 2001 Feb 15;44(4):548-65. doi: 10.1021/jm001079l. J Med Chem. 2001. PMID: 11170645

10

Bisphosphonates inhibit the growth of Trypanosoma brucei, Trypanosoma cruzi, Leishmania donovani, Toxoplasma gondii, and Plasmodium falciparum: a potential route to chemotherapy.

Martin MB, Grimley JS, Lewis JC, Heath HT 3rd, Bailey BN, Kendrick H, Yardley V, Caldera A, Lira R, Urbina JA, Moreno SN, Docampo R, Croft SL, Oldfield E. Martin MB, et al. Among authors: yardley v. J Med Chem. 2001 Mar 15;44(6):909-16. doi: 10.1021/jm0002578. J Med Chem. 2001. PMID: 11300872

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