Ellerby L - Search Results

1

Length of huntingtin and its polyglutamine tract influences localization and frequency of intracellular aggregates.

Martindale D, Hackam A, Wieczorek A, Ellerby L, Wellington C, McCutcheon K, Singaraja R, Kazemi-Esfarjani P, Devon R, Kim SU, Bredesen DE, Tufaro F, Hayden MR. Martindale D, et al. Among authors: ellerby l. Nat Genet. 1998 Feb;18(2):150-4. doi: 10.1038/ng0298-150. Nat Genet. 1998. PMID: 9462744

2

Inhibiting caspase cleavage of huntingtin reduces toxicity and aggregate formation in neuronal and nonneuronal cells.

Wellington CL, Singaraja R, Ellerby L, Savill J, Roy S, Leavitt B, Cattaneo E, Hackam A, Sharp A, Thornberry N, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: ellerby l. J Biol Chem. 2000 Jun 30;275(26):19831-8. doi: 10.1074/jbc.M001475200. J Biol Chem. 2000. PMID: 10770929 Free article.

3

Caspase cleavage of mutant huntingtin precedes neurodegeneration in Huntington's disease.

Wellington CL, Ellerby LM, Gutekunst CA, Rogers D, Warby S, Graham RK, Loubser O, van Raamsdonk J, Singaraja R, Yang YZ, Gafni J, Bredesen D, Hersch SM, Leavitt BR, Roy S, Nicholson DW, Hayden MR. Wellington CL, et al. Among authors: ellerby lm. J Neurosci. 2002 Sep 15;22(18):7862-72. doi: 10.1523/JNEUROSCI.22-18-07862.2002. J Neurosci. 2002. PMID: 12223539 Free PMC article.

4

Caspase cleavage of gene products associated with triplet expansion disorders generates truncated fragments containing the polyglutamine tract.

Wellington CL, Ellerby LM, Hackam AS, Margolis RL, Trifiro MA, Singaraja R, McCutcheon K, Salvesen GS, Propp SS, Bromm M, Rowland KJ, Zhang T, Rasper D, Roy S, Thornberry N, Pinsky L, Kakizuka A, Ross CA, Nicholson DW, Bredesen DE, Hayden MR. Wellington CL, et al. Among authors: ellerby lm. J Biol Chem. 1998 Apr 10;273(15):9158-67. doi: 10.1074/jbc.273.15.9158. J Biol Chem. 1998. PMID: 9535906 Free article.

5

Double-stranded RNA-dependent protein kinase, PKR, binds preferentially to Huntington's disease (HD) transcripts and is activated in HD tissue.

Peel AL, Rao RV, Cottrell BA, Hayden MR, Ellerby LM, Bredesen DE. Peel AL, et al. Among authors: ellerby lm. Hum Mol Genet. 2001 Jul 15;10(15):1531-8. doi: 10.1093/hmg/10.15.1531. Hum Mol Genet. 2001. PMID: 11468270

6

Inhibition of calpain cleavage of huntingtin reduces toxicity: accumulation of calpain/caspase fragments in the nucleus.

Gafni J, Hermel E, Young JE, Wellington CL, Hayden MR, Ellerby LM. Gafni J, et al. Among authors: ellerby lm. J Biol Chem. 2004 May 7;279(19):20211-20. doi: 10.1074/jbc.M401267200. Epub 2004 Feb 23. J Biol Chem. 2004. PMID: 14981075 Free article.

7

Cleavage of atrophin-1 at caspase site aspartic acid 109 modulates cytotoxicity.

Ellerby LM, Andrusiak RL, Wellington CL, Hackam AS, Propp SS, Wood JD, Sharp AH, Margolis RL, Ross CA, Salvesen GS, Hayden MR, Bredesen DE. Ellerby LM, et al. J Biol Chem. 1999 Mar 26;274(13):8730-6. doi: 10.1074/jbc.274.13.8730. J Biol Chem. 1999. PMID: 10085113 Free article.

8

Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease.

Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE, Hackam AS, Logvinova AV, Peel AL, Chen SF, Hook V, Singaraja R, Krajewski S, Goldsmith PC, Ellerby HM, Hayden MR, Bredesen DE, Ellerby LM. Hermel E, et al. Among authors: ellerby lm, ellerby hm. Cell Death Differ. 2004 Apr;11(4):424-38. doi: 10.1038/sj.cdd.4401358. Cell Death Differ. 2004. PMID: 14713958

9

Nuclear localization of a non-caspase truncation product of atrophin-1, with an expanded polyglutamine repeat, increases cellular toxicity.

Nucifora FC Jr, Ellerby LM, Wellington CL, Wood JD, Herring WJ, Sawa A, Hayden MR, Dawson VL, Dawson TM, Ross CA. Nucifora FC Jr, et al. Among authors: ellerby lm. J Biol Chem. 2003 Apr 11;278(15):13047-55. doi: 10.1074/jbc.M211224200. Epub 2002 Dec 2. J Biol Chem. 2003. PMID: 12464607 Free article.

10

Kennedy's disease: caspase cleavage of the androgen receptor is a crucial event in cytotoxicity.

Ellerby LM, Hackam AS, Propp SS, Ellerby HM, Rabizadeh S, Cashman NR, Trifiro MA, Pinsky L, Wellington CL, Salvesen GS, Hayden MR, Bredesen DE. Ellerby LM, et al. Among authors: ellerby hm. J Neurochem. 1999 Jan;72(1):185-95. doi: 10.1046/j.1471-4159.1999.0720185.x. J Neurochem. 1999. PMID: 9886069 Free article.

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