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Page 1
Aggrecan protects cartilage collagen from proteolytic cleavage.
Pratta MA, Yao W, Decicco C, Tortorella MD, Liu RQ, Copeland RA, Magolda R, Newton RC, Trzaskos JM, Arner EC. Pratta MA, et al. Among authors: tortorella md. J Biol Chem. 2003 Nov 14;278(46):45539-45. doi: 10.1074/jbc.M303737200. Epub 2003 Jul 30. J Biol Chem. 2003. PMID: 12890681 Free article.
Design and synthesis of a series of (2R)-N(4)-hydroxy-2-(3-hydroxybenzyl)-N(1)- [(1S,2R)-2-hydroxy-2,3-dihydro-1H-inden-1-yl]butanediamide derivatives as potent, selective, and orally bioavailable aggrecanase inhibitors.
Yao W, Wasserman ZR, Chao M, Reddy G, Shi E, Liu RQ, Covington MB, Arner EC, Pratta MA, Tortorella M, Magolda RL, Newton R, Qian M, Ribadeneira MD, Christ D, Wexler RR, Decicco CP. Yao W, et al. Among authors: tortorella m. J Med Chem. 2001 Oct 11;44(21):3347-50. doi: 10.1021/jm015533c. J Med Chem. 2001. PMID: 11585439
Purification and cloning of aggrecanase-1: a member of the ADAMTS family of proteins.
Tortorella MD, Burn TC, Pratta MA, Abbaszade I, Hollis JM, Liu R, Rosenfeld SA, Copeland RA, Decicco CP, Wynn R, Rockwell A, Yang F, Duke JL, Solomon K, George H, Bruckner R, Nagase H, Itoh Y, Ellis DM, Ross H, Wiswall BH, Murphy K, Hillman MC Jr, Hollis GF, Newton RC, Magolda RL, Trzaskos JM, Arner EC. Tortorella MD, et al. Science. 1999 Jun 4;284(5420):1664-6. doi: 10.1126/science.284.5420.1664. Science. 1999. PMID: 10356395
81 results