Imbach PA - Search Results

1

Ethnobotanical-directed discovery of the antihyperglycemic properties of cryptolepine: its isolation from Cryptolepis sanguinolenta, synthesis, and in vitro and in vivo activities.

Bierer DE, Fort DM, Mendez CD, Luo J, Imbach PA, Dubenko LG, Jolad SD, Gerber RE, Litvak J, Lu Q, Zhang P, Reed MJ, Waldeck N, Bruening RC, Noamesi BK, Hector RF, Carlson TJ, King SR. Bierer DE, et al. Among authors: imbach pa. J Med Chem. 1998 Mar 12;41(6):894-901. doi: 10.1021/jm9704816. J Med Chem. 1998. PMID: 9526563

2

Antihyperglycemic activities of cryptolepine analogues: an ethnobotanical lead structure isolated from Cryptolepis sanguinolenta.

Bierer DE, Dubenko LG, Zhang P, Lu Q, Imbach PA, Garofalo AW, Phuan PW, Fort DM, Litvak J, Gerber RE, Sloan B, Luo J, Cooper R, Reaven GM. Bierer DE, et al. Among authors: imbach pa. J Med Chem. 1998 Jul 16;41(15):2754-64. doi: 10.1021/jm970735n. J Med Chem. 1998. PMID: 9667966

3

2,6,9-trisubstituted purines: optimization towards highly potent and selective CDK1 inhibitors.

Imbach P, Capraro HG, Furet P, Mett H, Meyer T, Zimmermann J. Imbach P, et al. Bioorg Med Chem Lett. 1999 Jan 4;9(1):91-6. doi: 10.1016/s0960-894x(98)00691-x. Bioorg Med Chem Lett. 1999. PMID: 9990463

4

Modeling of the binding mode of a non-covalent inhibitor of the 20S proteasome. Application to structure-based analogue design.

Furet P, Imbach P, Fürst P, Lang M, Noorani M, Zimmermann J, García-Echeverria C. Furet P, et al. Bioorg Med Chem Lett. 2001 May 21;11(10):1321-4. doi: 10.1016/s0960-894x(01)00206-2. Bioorg Med Chem Lett. 2001. PMID: 11392546

5

Entry into a new class of potent proteasome inhibitors having high antiproliferative activity by structure-based design.

Furet P, Imbach P, Noorani M, Koeppler J, Laumen K, Lang M, Guagnano V, Fuerst P, Roesel J, Zimmermann J, García-Echeverría C. Furet P, et al. J Med Chem. 2004 Sep 23;47(20):4810-3. doi: 10.1021/jm049660v. J Med Chem. 2004. PMID: 15369383 Free article.

6

Structure-based design of potent CDK1 inhibitors derived from olomoucine.

Furet P, Zimmermann J, Capraro HG, Meyer T, Imbach P. Furet P, et al. J Comput Aided Mol Des. 2000 Jul;14(5):403-9. doi: 10.1023/a:1008115004986. J Comput Aided Mol Des. 2000. PMID: 10896313

7

The small molecule specific EphB4 kinase inhibitor NVP-BHG712 inhibits VEGF driven angiogenesis.

Martiny-Baron G, Holzer P, Billy E, Schnell C, Brueggen J, Ferretti M, Schmiedeberg N, Wood JM, Furet P, Imbach P. Martiny-Baron G, et al. Angiogenesis. 2010 Sep;13(3):259-67. doi: 10.1007/s10456-010-9183-z. Epub 2010 Aug 29. Angiogenesis. 2010. PMID: 20803239 Free PMC article.

8

Antileukemic Effects of Novel First- and Second-Generation FLT3 Inhibitors: Structure-Affinity Comparison.

Weisberg E, Roesel J, Furet P, Bold G, Imbach P, Flörsheimer A, Caravatti G, Jiang J, Manley P, Ray A, Griffin JD. Weisberg E, et al. Genes Cancer. 2010 Oct;1(10):1021-32. doi: 10.1177/1947601910396505. Genes Cancer. 2010. PMID: 21779428 Free PMC article.

9

Novel beta-lactam derivatives: potent and selective inhibitors of the chymotrypsin-like activity of the human 20S proteasome.

Imbach P, Lang M, García-Echeverría C, Guagnano V, Noorani M, Roesel J, Bitsch F, Rihs G, Furet P. Imbach P, et al. Bioorg Med Chem Lett. 2007 Jan 15;17(2):358-62. doi: 10.1016/j.bmcl.2006.10.047. Epub 2006 Oct 24. Bioorg Med Chem Lett. 2007. PMID: 17095212

10

A new structural class of selective and non-covalent inhibitors of the chymotrypsin-like activity of the 20S proteasome.

García-Echeverría C, Imbach P, France D, Fürst P, Lang M, Noorani AM, Scholz D, Zimmermann J, Furet P. García-Echeverría C, et al. Bioorg Med Chem Lett. 2001 May 21;11(10):1317-9. doi: 10.1016/s0960-894x(01)00205-0. Bioorg Med Chem Lett. 2001. PMID: 11392545

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