Nelson SD - Search Results

1

(R)-(+)-Menthofuran is a potent, mechanism-based inactivator of human liver cytochrome P450 2A6.

Khojasteh-Bakht SC, Koenigs LL, Peter RM, Trager WF, Nelson SD. Khojasteh-Bakht SC, et al. Among authors: nelson sd. Drug Metab Dispos. 1998 Jul;26(7):701-4. Drug Metab Dispos. 1998. PMID: 9660853

2

The use of deuterium isotope effects to probe the active site properties, mechanism of cytochrome P450-catalyzed reactions, and mechanisms of metabolically dependent toxicity.

Nelson SD, Trager WF. Nelson SD, et al. Drug Metab Dispos. 2003 Dec;31(12):1481-98. doi: 10.1124/dmd.31.12.1481. Drug Metab Dispos. 2003. PMID: 14625345 Review.

3

Oxidation of acetaminophen to its toxic quinone imine and nontoxic catechol metabolites by baculovirus-expressed and purified human cytochromes P450 2E1 and 2A6.

Chen W, Koenigs LL, Thompson SJ, Peter RM, Rettie AE, Trager WF, Nelson SD. Chen W, et al. Among authors: nelson sd. Chem Res Toxicol. 1998 Apr;11(4):295-301. doi: 10.1021/tx9701687. Chem Res Toxicol. 1998. PMID: 9548799

4

Metabolism of (R)-(+)-pulegone and (R)-(+)-menthofuran by human liver cytochrome P-450s: evidence for formation of a furan epoxide.

Khojasteh-Bakht SC, Chen W, Koenigs LL, Peter RM, Nelson SD. Khojasteh-Bakht SC, et al. Among authors: nelson sd. Drug Metab Dispos. 1999 May;27(5):574-80. Drug Metab Dispos. 1999. PMID: 10220485

5

Oxidation of caffeine by CYP1A2: isotope effects and metabolic switching.

Regal KA, Kunze KL, Peter RM, Nelson SD. Regal KA, et al. Among authors: nelson sd. Drug Metab Dispos. 2005 Dec;33(12):1837-44. doi: 10.1124/dmd.105.006031. Epub 2005 Aug 31. Drug Metab Dispos. 2005. PMID: 16135658

6

Baculovirus expression and purification of human and rat cytochrome P450 2E1.

Chen W, Peter RM, McArdle S, Thummel KE, Sigle RO, Nelson SD. Chen W, et al. Among authors: nelson sd. Arch Biochem Biophys. 1996 Nov 1;335(1):123-30. doi: 10.1006/abbi.1996.0489. Arch Biochem Biophys. 1996. PMID: 8914842

7

Glutathione S-transferase catalyzes the isomerization of (R)-2-hydroxymenthofuran to mintlactones.

Khojasteh-Bakht SC, Nelson SD, Atkins WM. Khojasteh-Bakht SC, et al. Among authors: nelson sd. Arch Biochem Biophys. 1999 Oct 1;370(1):59-65. doi: 10.1006/abbi.1999.1361. Arch Biochem Biophys. 1999. PMID: 10496977

8

Subnanomolar quantification of caffeine's in vitro metabolites by stable isotope dilution gas chromatography-mass spectrometry.

Regal KA, Howald WN, Peter RM, Gartner CA, Kunze KL, Nelson SD. Regal KA, et al. Among authors: nelson sd. J Chromatogr B Biomed Sci Appl. 1998 Apr 24;708(1-2):75-85. doi: 10.1016/s0378-4347(97)00656-7. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9653949

9

Mechanism of cytochrome P450 activation by caffeine and 7,8-benzoflavone in rat liver microsomes.

Lee CA, Manyike PT, Thummel KE, Nelson SD, Slattery JT. Lee CA, et al. Among authors: nelson sd. Drug Metab Dispos. 1997 Oct;25(10):1150-6. Drug Metab Dispos. 1997. PMID: 9321518

10

Metabolic intermediate complex formation of human cytochrome P450 3A4 by lapatinib.

Takakusa H, Wahlin MD, Zhao C, Hanson KL, New LS, Chan EC, Nelson SD. Takakusa H, et al. Among authors: nelson sd. Drug Metab Dispos. 2011 Jun;39(6):1022-30. doi: 10.1124/dmd.110.037531. Epub 2011 Mar 1. Drug Metab Dispos. 2011. PMID: 21363997 Free PMC article.

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