Bolton JL - Search Results

1

Inhibition of glutathione S-transferase activity by the quinoid metabolites of equine estrogens.

Chang M, Zhang F, Shen L, Pauss N, Alam I, van Breemen RB, Blond SY, Bolton JL. Chang M, et al. Among authors: bolton jl. Chem Res Toxicol. 1998 Jul;11(7):758-65. doi: 10.1021/tx9702190. Chem Res Toxicol. 1998. PMID: 9671538

2

Bioactivation of estrone and its catechol metabolites to quinoid-glutathione conjugates in rat liver microsomes.

Iverson SL, Shen L, Anlar N, Bolton JL. Iverson SL, et al. Among authors: bolton jl. Chem Res Toxicol. 1996 Mar;9(2):492-9. doi: 10.1021/tx950178c. Chem Res Toxicol. 1996. PMID: 8839054

3

Alkylation of 2'-deoxynucleosides and DNA by the Premarin metabolite 4-hydroxyequilenin semiquinone radical.

Shen L, Qiu S, Chen Y, Zhang F, van Breemen RB, Nikolic D, Bolton JL. Shen L, et al. Among authors: bolton jl. Chem Res Toxicol. 1998 Feb;11(2):94-101. doi: 10.1021/tx970181r. Chem Res Toxicol. 1998. PMID: 9511900

4

The equine estrogen metabolite 4-hydroxyequilenin causes DNA single-strand breaks and oxidation of DNA bases in vitro.

Chen Y, Shen L, Zhang F, Lau SS, van Breemen RB, Nikolic D, Bolton JL. Chen Y, et al. Among authors: bolton jl. Chem Res Toxicol. 1998 Sep;11(9):1105-11. doi: 10.1021/tx980083l. Chem Res Toxicol. 1998. PMID: 9760286

5

Role of quinoids in estrogen carcinogenesis.

Bolton JL, Pisha E, Zhang F, Qiu S. Bolton JL, et al. Chem Res Toxicol. 1998 Oct;11(10):1113-27. doi: 10.1021/tx9801007. Chem Res Toxicol. 1998. PMID: 9778307 Review. No abstract available.

6

Synthesis of the equine estrogen metabolites 2-hydroxyequilin and 2-hydroxyequilenin.

Zhang F, Bolton JL. Zhang F, et al. Among authors: bolton jl. Chem Res Toxicol. 1999 Feb;12(2):200-3. doi: 10.1021/tx980189g. Chem Res Toxicol. 1999. PMID: 10027799

7

The major metabolite of equilin, 4-hydroxyequilin, autoxidizes to an o-quinone which isomerizes to the potent cytotoxin 4-hydroxyequilenin-o-quinone.

Zhang F, Chen Y, Pisha E, Shen L, Xiong Y, van Breemen RB, Bolton JL. Zhang F, et al. Among authors: bolton jl. Chem Res Toxicol. 1999 Feb;12(2):204-13. doi: 10.1021/tx980217v. Chem Res Toxicol. 1999. PMID: 10027800

8

4-Hydroxylated metabolites of the antiestrogens tamoxifen and toremifene are metabolized to unusually stable quinone methides.

Fan PW, Zhang F, Bolton JL. Fan PW, et al. Among authors: bolton jl. Chem Res Toxicol. 2000 Jan;13(1):45-52. doi: 10.1021/tx990144v. Chem Res Toxicol. 2000. PMID: 10649966

9

Synthesis and reactivity of a potential carcinogenic metabolite of tamoxifen: 3,4-dihydroxytamoxifen-o-quinone.

Zhang F, Fan PW, Liu X, Shen L, van Breemen RB, Bolton JL. Zhang F, et al. Among authors: bolton jl. Chem Res Toxicol. 2000 Jan;13(1):53-62. doi: 10.1021/tx990145n. Chem Res Toxicol. 2000. PMID: 10649967

10

A metabolite of equine estrogens, 4-hydroxyequilenin, induces DNA damage and apoptosis in breast cancer cell lines.

Chen Y, Liu X, Pisha E, Constantinou AI, Hua Y, Shen L, van Breemen RB, Elguindi EC, Blond SY, Zhang F, Bolton JL. Chen Y, et al. Among authors: bolton jl. Chem Res Toxicol. 2000 May;13(5):342-50. doi: 10.1021/tx990186j. Chem Res Toxicol. 2000. PMID: 10813650

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