McPhail AT - Search Results

1

Synthesis of isomeric 3-piperidinyl and 3-pyrrolidinyl benzo[5,6]cyclohepta[1,2-b]pyridines: sulfonamido derivatives as inhibitors of Ras prenylation.

Kelly J, Wolin R, Connolly M, Afonso A, James L, Kirshmeier P, Bishop WR, McPhail AT. Kelly J, et al. Among authors: mcphail at. Bioorg Med Chem. 1998 Jun;6(6):673-86. doi: 10.1016/s0968-0896(98)00026-1. Bioorg Med Chem. 1998. PMID: 9681133

2

Acid-Catalyzed Rearrangement of 5-Bromo-3-[1-allyl-2-(3,5-dimethoxyphenyl)ethyl]-2-cyanopyridine.

Kelly J, Puar MS, Afonso A, McPhail AT. Kelly J, et al. Among authors: mcphail at. J Org Chem. 1998 Aug 21;63(17):6039-6042. doi: 10.1021/jo9803378. J Org Chem. 1998. PMID: 11672213 No abstract available.

3

Synthesis and NK(1)/NK(2) binding activities of a series of diacyl-substituted 2-arylpiperazines.

Blythin DJ, Chen X, Piwinski JJ, Shih NY, Shue HJ, Anthes JC, McPhail AT. Blythin DJ, et al. Among authors: mcphail at. Bioorg Med Chem Lett. 2002 Nov 4;12(21):3161-5. doi: 10.1016/s0960-894x(02)00645-5. Bioorg Med Chem Lett. 2002. PMID: 12372524

4

Synthesis of C3 heteroatom-substituted azetidinones that display potent cholesterol absorption inhibitory activity.

McKittrick BA, Ma K, Huie K, Yumibe N, Davis H Jr, Clader JW, Czarniecki M, McPhail AT. McKittrick BA, et al. Among authors: mcphail at. J Med Chem. 1998 Feb 26;41(5):752-9. doi: 10.1021/jm970676d. J Med Chem. 1998. PMID: 9513603

5

Himbacine derived thrombin receptor (PAR-1) antagonists: structure-activity relationship of the lactone ring.

Xia Y, Chackalamannil S, Chan TM, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Tsai H, Wang Y, Ahn HS, Boykow GC, McPhail AT. Xia Y, et al. Among authors: mcphail at. Bioorg Med Chem Lett. 2006 Sep 15;16(18):4969-72. doi: 10.1016/j.bmcl.2006.06.042. Epub 2006 Jul 7. Bioorg Med Chem Lett. 2006. PMID: 16824760

6

Himbacine derived thrombin receptor antagonists: discovery of a new tricyclic core.

Clasby MC, Chackalamannil S, Czarniecki M, Doller D, Eagen K, Greenlee WJ, Lin Y, Tagat JR, Tsai H, Xia Y, Ahn HS, Agans-Fantuzzi J, Boykow G, Chintala M, Hsieh Y, McPhail AT. Clasby MC, et al. Among authors: mcphail at. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3647-51. doi: 10.1016/j.bmcl.2007.04.061. Epub 2007 Apr 25. Bioorg Med Chem Lett. 2007. PMID: 17490877

7

Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine.

Kaminski JJ, Carruthers NI, Wong SC, Chan TM, Billah MM, Tozzi S, McPhail AT. Kaminski JJ, et al. Among authors: mcphail at. Bioorg Med Chem. 1999 Jul;7(7):1413-23. doi: 10.1016/s0968-0896(99)00075-9. Bioorg Med Chem. 1999. PMID: 10465415

8

Design and synthesis of tricyclic sulfones as gamma-secretase inhibitors with greatly reduced Notch toxicity.

Xu R, Cole D, Asberom T, Bara T, Bennett C, Burnett DA, Clader J, Domalski M, Greenlee W, Hyde L, Josien H, Li H, McBriar M, McKittrick B, McPhail AT, Pissarnitski D, Qiang L, Rajagopalan M, Sasikumar T, Su J, Tang H, Wu WL, Zhang L, Zhao Z. Xu R, et al. Among authors: mcphail at. Bioorg Med Chem Lett. 2010 Apr 15;20(8):2591-6. doi: 10.1016/j.bmcl.2010.02.080. Epub 2010 Feb 23. Bioorg Med Chem Lett. 2010. PMID: 20236824

9

Discovery of gamma-secretase inhibitors efficacious in a transgenic animal model of Alzheimer's disease.

Asberom T, Zhao Z, Bara TA, Clader JW, Greenlee WJ, Hyde LA, Josien HB, Li W, McPhail AT, Nomeir AA, Parker EM, Rajagopalan M, Song L, Wong GT, Zhang L, Zhang Q, Pissarnitski DA. Asberom T, et al. Among authors: mcphail at. Bioorg Med Chem Lett. 2007 Jan 15;17(2):511-6. doi: 10.1016/j.bmcl.2006.10.011. Epub 2006 Oct 10. Bioorg Med Chem Lett. 2007. PMID: 17079141

10

Spiro-piperidine azetidinones as potent TRPV1 antagonists.

Xiao D, Palani A, Aslanian R, McKittrick BA, McPhail AT, Correll CC, Phelps PT, Anthes JC, Rindgen D. Xiao D, et al. Among authors: mcphail at. Bioorg Med Chem Lett. 2009 Feb 1;19(3):783-7. doi: 10.1016/j.bmcl.2008.12.024. Epub 2008 Dec 10. Bioorg Med Chem Lett. 2009. PMID: 19114307

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