Henne KR - Search Results

1

Chiral phase analysis of warfarin enantiomers in patient plasma in relation to CYP2C9 genotype.

Henne KR, Gaedigk A, Gupta G, Leeder JS, Rettie AE. Henne KR, et al. J Chromatogr B Biomed Sci Appl. 1998 Jun 12;710(1-2):143-8. doi: 10.1016/s0378-4347(98)00099-1. J Chromatogr B Biomed Sci Appl. 1998. PMID: 9686881

2

Genetic association between sensitivity to warfarin and expression of CYP2C9*3.

Steward DJ, Haining RL, Henne KR, Davis G, Rushmore TH, Trager WF, Rettie AE. Steward DJ, et al. Among authors: henne kr. Pharmacogenetics. 1997 Oct;7(5):361-7. doi: 10.1097/00008571-199710000-00004. Pharmacogenetics. 1997. PMID: 9352571

3

Enzymatic determinants of the substrate specificity of CYP2C9: role of B'-C loop residues in providing the pi-stacking anchor site for warfarin binding.

Haining RL, Jones JP, Henne KR, Fisher MB, Koop DR, Trager WF, Rettie AE. Haining RL, et al. Among authors: henne kr. Biochemistry. 1999 Mar 16;38(11):3285-92. doi: 10.1021/bi982161+. Biochemistry. 1999. PMID: 10079071

4

Bioactivation of 4-ipomeanol by CYP4B1: adduct characterization and evidence for an enedial intermediate.

Baer BR, Rettie AE, Henne KR. Baer BR, et al. Among authors: henne kr. Chem Res Toxicol. 2005 May;18(5):855-64. doi: 10.1021/tx0496993. Chem Res Toxicol. 2005. PMID: 15892579

5

Active site characteristics of CYP4B1 probed with aromatic ligands.

Henne KR, Fisher MB, Iyer KR, Lang DH, Trager WF, Rettie AE. Henne KR, et al. Biochemistry. 2001 Jul 24;40(29):8597-605. doi: 10.1021/bi010395e. Biochemistry. 2001. PMID: 11456500

6

Covalent linkage of prosthetic heme to CYP4 family P450 enzymes.

Henne KR, Kunze KL, Zheng YM, Christmas P, Soberman RJ, Rettie AE. Henne KR, et al. Biochemistry. 2001 Oct 30;40(43):12925-31. doi: 10.1021/bi011171z. Biochemistry. 2001. PMID: 11669629

7

Covalent heme binding to CYP4B1 via Glu310 and a carbocation porphyrin intermediate.

Zheng YM, Baer BR, Kneller MB, Henne KR, Kunze KL, Rettie AE. Zheng YM, et al. Among authors: henne kr. Biochemistry. 2003 Apr 22;42(15):4601-6. doi: 10.1021/bi020667t. Biochemistry. 2003. PMID: 12693958

8

Genotyping and site-directed mutagenesis of a cytochrome P450 meander Pro-X-Arg motif critical to CYP4B1 catalysis.

Zheng YM, Henne KR, Charmley P, Kim RB, McCarver DG, Cabacungan ET, Hines RN, Rettie AE. Zheng YM, et al. Among authors: henne kr. Toxicol Appl Pharmacol. 2003 Jan 15;186(2):119-26. doi: 10.1016/s0041-008x(02)00028-5. Toxicol Appl Pharmacol. 2003. PMID: 12639503

9

A comparison of substrate dynamics in human CYP2E1 and CYP2A6.

Harrelson JP, Henne KR, Alonso DO, Nelson SD. Harrelson JP, et al. Among authors: henne kr. Biochem Biophys Res Commun. 2007 Jan 26;352(4):843-9. doi: 10.1016/j.bbrc.2006.11.071. Epub 2006 Nov 27. Biochem Biophys Res Commun. 2007. PMID: 17156750 Free PMC article.

10

The complexities inherent in attempts to decrease drug clearance by blocking sites of CYP-mediated metabolism.

Fisher MB, Henne KR, Boer J. Fisher MB, et al. Among authors: henne kr. Curr Opin Drug Discov Devel. 2006 Jan;9(1):101-9. Curr Opin Drug Discov Devel. 2006. PMID: 16445122 Review.

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