Ostrowski T - Search Results

1

Exploring the active site of herpes simplex virus type-1 thymidine kinase by X-ray crystallography of complexes with aciclovir and other ligands.

Champness JN, Bennett MS, Wien F, Visse R, Summers WC, Herdewijn P, de Clerq E, Ostrowski T, Jarvest RL, Sanderson MR. Champness JN, et al. Among authors: ostrowski t. Proteins. 1998 Aug 15;32(3):350-61. doi: 10.1002/(sici)1097-0134(19980815)32:3<350::aid-prot10>3.0.co;2-8. Proteins. 1998. PMID: 9715911

2

5-Substituted pyrimidines with a 1,5-anhydro-2, 3-dideoxy-D-arabino-hexitol moiety at N-1: synthesis, antiviral activity, conformational analysis, and interaction with viral thymidine kinase.

Ostrowski T, Wroblowski B, Busson R, Rozenski J, De Clercq E, Bennett MS, Champness JN, Summers WC, Sanderson MR, Herdewijn P. Ostrowski T, et al. J Med Chem. 1998 Oct 22;41(22):4343-53. doi: 10.1021/jm980287z. J Med Chem. 1998. PMID: 9784109

3

Pronounced cytostatic activity and bystander effect of a novel series of fluorescent tricyclic acyclovir and ganciclovir derivatives in herpes simplex virus thymidine kinase gene-transduced tumor cell lines.

Balzarini J, Ostrowski T, Goslinski T, De Clercq E, Golankiewicz B. Balzarini J, et al. Among authors: ostrowski t. Gene Ther. 2002 Sep;9(17):1173-82. doi: 10.1038/sj.gt.3301779. Gene Ther. 2002. PMID: 12170381

4

Herpesvirus-encoded thymidine kinase in chemotherapy.

Ostrowski T, Nowotna J, Golankiewicz B. Ostrowski T, et al. Postepy Biochem. 1995;41(5 Suppl):342-7. Postepy Biochem. 1995. PMID: 8797235 Review. No abstract available.

5

Fluorosubstitution and 7-alkylation as prospective modifications of biologically active 6-aryl derivatives of tricyclic acyclovir and ganciclovir analogues.

Ostrowski T, Golankiewicz B, De Clercq E, Balzarini J. Ostrowski T, et al. Bioorg Med Chem. 2005 Mar 15;13(6):2089-96. doi: 10.1016/j.bmc.2005.01.004. Bioorg Med Chem. 2005. PMID: 15727862

6

Aminoacyl-tRNA synthetase inhibitors as potent and synergistic immunosuppressants.

Van de Vijver P, Ostrowski T, Sproat B, Goebels J, Rutgeerts O, Van Aerschot A, Waer M, Herdewijn P. Van de Vijver P, et al. Among authors: ostrowski t. J Med Chem. 2008 May 22;51(10):3020-9. doi: 10.1021/jm8000746. Epub 2008 Apr 26. J Med Chem. 2008. PMID: 18438987

7

Tricyclic analogues of acyclovir and ganciclovir. Influence of substituents in the heterocyclic moiety on the antiviral activity.

Golankiewicz B, Ostrowski T, Andrei G, Snoeck R, De Clercq E. Golankiewicz B, et al. Among authors: ostrowski t. J Med Chem. 1994 Sep 16;37(19):3187-90. doi: 10.1021/jm00045a025. J Med Chem. 1994. PMID: 7932543

8

Fluorescent tricyclic analogues of acyclovir and ganciclovir. A structure-antiviral activity study.

Golankiewicz B, Ostrowski T, Goslinski T, Januszczyk P, Zeidler J, Baranowski D, de Clercq E. Golankiewicz B, et al. Among authors: ostrowski t. J Med Chem. 2001 Nov 22;44(24):4284-7. doi: 10.1021/jm010922s. J Med Chem. 2001. PMID: 11708929

9

Synthesis and biological activity of tricyclic analogues of 9-[[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl]guanine.

Ostrowski T, Golankiewicz B, De Clercq E, Balzarini J. Ostrowski T, et al. Bioorg Med Chem. 2006 May 15;14(10):3535-42. doi: 10.1016/j.bmc.2006.01.014. Epub 2006 Feb 2. Bioorg Med Chem. 2006. PMID: 16458009

10

Synthesis and anti-VZV activity of 6-heteroaryl derivatives of tricyclic acyclovir and 9-{[cis-1',2'-bis(hydroxymethyl)cycloprop-1'-yl]methyl}guanine analogues.

Ostrowski T, Golankiewicz B, De Clercq E, Andrei G, Snoeck R. Ostrowski T, et al. Eur J Med Chem. 2009 Aug;44(8):3313-7. doi: 10.1016/j.ejmech.2009.03.005. Epub 2009 Mar 21. Eur J Med Chem. 2009. PMID: 19339082

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