Workman P - Search Results

1

Preclinical development and current status of the fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR 4554, CRC 94/17): a non-invasive diagnostic probe for the measurement of tumor hypoxia by magnetic resonance spectroscopy and imaging, and by positron emission tomography.

Aboagye EO, Kelson AB, Tracy M, Workman P. Aboagye EO, et al. Among authors: workman p. Anticancer Drug Des. 1998 Sep;13(6):703-30. Anticancer Drug Des. 1998. PMID: 9755726 Review.

2

The pharmacokinetics, bioavailability and biodistribution in mice of a rationally designed 2-nitroimidazole hypoxia probe SR-4554.

Aboagye EO, Lewis AD, Graham MA, Tracy M, Kelson AB, Ryan KJ, Workman P. Aboagye EO, et al. Among authors: workman p. Anticancer Drug Des. 1996 Apr;11(3):231-42. Anticancer Drug Des. 1996. PMID: 8663910

3

Preclinical evaluation of the fluorinated 2-nitroimidazole N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitro-1-imidazolyl) acetamide (SR-4554) as a probe for the measurement of tumor hypoxia.

Aboagye EO, Maxwell RJ, Kelson AB, Tracy M, Lewis AD, Graham MA, Horsman MR, Griffiths JR, Workman P. Aboagye EO, et al. Among authors: workman p. Cancer Res. 1997 Aug 1;57(15):3314-8. Cancer Res. 1997. PMID: 9242466

4

The relationship between tumour oxygenation determined by oxygen electrode measurements and magnetic resonance spectroscopy of the fluorinated 2-nitroimidazole SR-4554.

Aboagye EO, Maxwell RJ, Horsman MR, Lewis AD, Workman P, Tracy M, Griffiths JR. Aboagye EO, et al. Among authors: workman p. Br J Cancer. 1998;77(1):65-70. doi: 10.1038/bjc.1998.10. Br J Cancer. 1998. PMID: 9459147 Free PMC article.

5

The novel fluorinated 2-nitroimidazole hypoxia probe SR-4554: reductive metabolism and semiquantitative localisation in human ovarian cancer multicellular spheroids as measured by electron energy loss spectroscopic analysis.

Aboagye EO, Lewis AD, Johnson A, Workman P, Tracy M, Huxham IM. Aboagye EO, et al. Among authors: workman p. Br J Cancer. 1995 Aug;72(2):312-8. doi: 10.1038/bjc.1995.330. Br J Cancer. 1995. PMID: 7640211 Free PMC article.

6

Development and validation of a solid-phase extraction and high-performance liquid chromatographic assay for a novel fluorinated 2-nitroimidazole hypoxia probe (SR-4554) in Balb/c mouse plasma.

Aboagye EO, Graham MA, Lewis AD, Workman P, Kelson AB, Tracy M. Aboagye EO, et al. Among authors: workman p. J Chromatogr B Biomed Appl. 1995 Oct 6;672(1):125-32. doi: 10.1016/0378-4347(95)00204-v. J Chromatogr B Biomed Appl. 1995. PMID: 8590924

7

Bioreductive metabolism of the novel fluorinated 2-nitroimidazole hypoxia probe N-(2-hydroxy-3,3,3-trifluoropropyl)-2-(2-nitroimidazolyl) acetamide (SR-4554).

Aboagye EO, Lewis AD, Tracy M, Workman P. Aboagye EO, et al. Among authors: workman p. Biochem Pharmacol. 1997 Dec 1;54(11):1217-24. doi: 10.1016/s0006-2952(97)00344-4. Biochem Pharmacol. 1997. PMID: 9416972 Free article.

8

In vivo evaluation of [18F]fluoroetanidazole as a new marker for imaging tumour hypoxia with positron emission tomography.

Barthel H, Wilson H, Collingridge DR, Brown G, Osman S, Luthra SK, Brady F, Workman P, Price PM, Aboagye EO. Barthel H, et al. Among authors: workman p. Br J Cancer. 2004 Jun 1;90(11):2232-42. doi: 10.1038/sj.bjc.6601862. Br J Cancer. 2004. PMID: 15150578 Free PMC article.

9

A phase I study of the nitroimidazole hypoxia marker SR4554 using 19F magnetic resonance spectroscopy.

Lee CP, Payne GS, Oregioni A, Ruddle R, Tan S, Raynaud FI, Eaton D, Campbell MJ, Cross K, Halbert G, Tracy M, McNamara J, Seddon B, Leach MO, Workman P, Judson I. Lee CP, et al. Among authors: workman p. Br J Cancer. 2009 Dec 1;101(11):1860-8. doi: 10.1038/sj.bjc.6605425. Br J Cancer. 2009. PMID: 19935799 Free PMC article. Clinical Trial.

10

In vivo biological activity of the histone deacetylase inhibitor LAQ824 is detectable with 3'-deoxy-3'-[18F]fluorothymidine positron emission tomography.

Leyton J, Alao JP, Da Costa M, Stavropoulou AV, Latigo JR, Perumal M, Pillai R, He Q, Atadja P, Lam EW, Workman P, Vigushin DM, Aboagye EO. Leyton J, et al. Among authors: workman p. Cancer Res. 2006 Aug 1;66(15):7621-9. doi: 10.1158/0008-5472.CAN-05-3962. Cancer Res. 2006. PMID: 16885362

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