Chapman AP - Search Results

1

F(ab')2 molecules made from Escherichia coli produced Fab' with hinge sequences conferring increased serum survival in an animal model.

Humphreys DP, Vetterlein OM, Chapman AP, King DJ, Antoniw P, Suitters AJ, Reeks DG, Parton TA, King LM, Smith BJ, Lang V, Stephens PE. Humphreys DP, et al. Among authors: chapman ap. J Immunol Methods. 1998 Aug 1;217(1-2):1-10. doi: 10.1016/s0022-1759(98)00061-1. J Immunol Methods. 1998. PMID: 9776570

2

Formation of dimeric Fabs in Escherichia coli: effect of hinge size and isotype, presence of interchain disulphide bond, Fab' expression levels, tail piece sequences and growth conditions.

Humphreys DP, Chapman AP, Reeks DG, Lang V, Stephens PE. Humphreys DP, et al. Among authors: chapman ap. J Immunol Methods. 1997 Dec 1;209(2):193-202. doi: 10.1016/s0022-1759(97)00172-5. J Immunol Methods. 1997. PMID: 9461335

3

Improved efficiency of site-specific copper(II) ion-catalysed protein cleavage effected by mutagenesis of cleavage site.

Humphreys DP, King LM, West SM, Chapman AP, Sehdev M, Redden MW, Glover DJ, Smith BJ, Stephens PE. Humphreys DP, et al. Among authors: chapman ap. Protein Eng. 2000 Mar;13(3):201-6. doi: 10.1093/protein/13.3.201. Protein Eng. 2000. PMID: 10775662

4

High-level periplasmic expression in Escherichia coli using a eukaryotic signal peptide: importance of codon usage at the 5' end of the coding sequence.

Humphreys DP, Sehdev M, Chapman AP, Ganesh R, Smith BJ, King LM, Glover DJ, Reeks DG, Stephens PE. Humphreys DP, et al. Among authors: chapman ap. Protein Expr Purif. 2000 Nov;20(2):252-64. doi: 10.1006/prep.2000.1286. Protein Expr Purif. 2000. PMID: 11049749

5

Prolonged in vivo residence times of antibody fragments associated with albumin.

Smith BJ, Popplewell A, Athwal D, Chapman AP, Heywood S, West SM, Carrington B, Nesbitt A, Lawson AD, Antoniw P, Eddelston A, Suitters A. Smith BJ, et al. Among authors: chapman ap. Bioconjug Chem. 2001 Sep-Oct;12(5):750-6. doi: 10.1021/bc010003g. Bioconjug Chem. 2001. PMID: 11562193

6

Therapeutic antibody fragments with prolonged in vivo half-lives.

Chapman AP, Antoniw P, Spitali M, West S, Stephens S, King DJ. Chapman AP, et al. Nat Biotechnol. 1999 Aug;17(8):780-3. doi: 10.1038/11717. Nat Biotechnol. 1999. PMID: 10429243

7

Formatting antibody fragments to mediate specific therapeutic functions.

Weir AN, Nesbitt A, Chapman AP, Popplewell AG, Antoniw P, Lawson AD. Weir AN, et al. Among authors: chapman ap. Biochem Soc Trans. 2002 Aug;30(4):512-6. doi: 10.1042/bst0300512. Biochem Soc Trans. 2002. PMID: 12196125 Review.

8

PEGylated antibodies and antibody fragments for improved therapy: a review.

Chapman AP. Chapman AP. Adv Drug Deliv Rev. 2002 Jun 17;54(4):531-45. doi: 10.1016/s0169-409x(02)00026-1. Adv Drug Deliv Rev. 2002. PMID: 12052713 Review.

9

Preparation and Biological Properties of Oligonucleotide-Functionalized Virus-like Particles.

Hincapie R, Bhattacharya S, Keshavarz-Joud P, Chapman AP, Crooke SN, Finn MG. Hincapie R, et al. Among authors: chapman ap. Biomacromolecules. 2023 Jun 12;24(6):2766-2776. doi: 10.1021/acs.biomac.3c00178. Epub 2023 May 31. Biomacromolecules. 2023. PMID: 37257068 Free PMC article.

10

N-glycosylation profiles of the SARS-CoV-2 spike D614G mutant and its ancestral protein characterized by advanced mass spectrometry.

Wang D, Zhou B, Keppel TR, Solano M, Baudys J, Goldstein J, Finn MG, Fan X, Chapman AP, Bundy JL, Woolfitt AR, Osman SH, Pirkle JL, Wentworth DE, Barr JR. Wang D, et al. Among authors: chapman ap. Sci Rep. 2021 Dec 7;11(1):23561. doi: 10.1038/s41598-021-02904-w. Sci Rep. 2021. PMID: 34876606 Free PMC article.

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