The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.
Totland MZ, Knudsen LM, Rasmussen NL, Omori Y, Sørensen V, Elster VCW, Stenersen JM, Larsen M, Jensen CL, Zickfeldt Lade AA, Bruusgaard E, Basing S, Kryeziu K, Brech A, Aasen T, Lothe RA, Leithe E.
Totland MZ, et al. Among authors: jensen cl.
Cell Mol Life Sci. 2024 Apr 10;81(1):171. doi: 10.1007/s00018-024-05165-8.
Cell Mol Life Sci. 2024.
PMID: 38597989
Free PMC article.