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Hyperthermic isolated limb perfusion with tumour necrosis factor-alpha and melphalan as palliative limb-saving treatment in patients with locally advanced soft-tissue sarcomas of the extremities with regional or distant metastases. Is it worthwhile?
Olieman AF, van Ginkel RJ, Molenaar WM, Schraffordt Koops H, Hoekstra HJ. Olieman AF, et al. Among authors: van ginkel rj. Arch Orthop Trauma Surg. 1998;118(1-2):70-4. doi: 10.1007/s004020050314. Arch Orthop Trauma Surg. 1998. PMID: 9833110
High plasma tumor necrosis factor (TNF)-alpha concentrations and a sepsis-like syndrome in patients undergoing hyperthermic isolated limb perfusion with recombinant TNF-alpha, interferon-gamma, and melphalan.
Zwaveling JH, Maring JK, Clarke FL, van Ginkel RJ, Limburg PC, Hoekstra HJ, Koops HS, Girbes AR. Zwaveling JH, et al. Among authors: van ginkel rj. Crit Care Med. 1996 May;24(5):765-70. doi: 10.1097/00003246-199605000-00007. Crit Care Med. 1996. PMID: 8706451 Clinical Trial.
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