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Dual D2-receptor and beta2-adrenoceptor agonists for the treatment of airway diseases. 1. Discovery and biological evaluation of some 7-(2-aminoethyl)-4-hydroxybenzothiazol-2(3H)-one analogues.
Bonnert RV, Brown RC, Chapman D, Cheshire DR, Dixon J, Ince F, Kinchin EC, Lyons AJ, Davis AM, Hallam C, Harper ST, Unitt JF, Dougall IG, Jackson DM, McKechnie K, Young A, Simpson WT. Bonnert RV, et al. Among authors: davis am. J Med Chem. 1998 Dec 3;41(25):4915-7. doi: 10.1021/jm980421f. J Med Chem. 1998. PMID: 9836607 No abstract available.
Switching between agonists and antagonists at CRTh2 in a series of highly potent and selective biaryl phenoxyacetic acids.
Luker T, Bonnert R, Schmidt J, Sargent C, Paine SW, Thom S, Pairaudeau G, Patel A, Mohammed R, Akam E, Dougall I, Davis AM, Abbott P, Brough S, Millichip I, McInally T. Luker T, et al. Among authors: davis am. Bioorg Med Chem Lett. 2011 Jun 15;21(12):3616-21. doi: 10.1016/j.bmcl.2011.04.101. Epub 2011 Apr 28. Bioorg Med Chem Lett. 2011. PMID: 21592791
Potent blockers of the monocarboxylate transporter MCT1: novel immunomodulatory compounds.
Guile SD, Bantick JR, Cheshire DR, Cooper ME, Davis AM, Donald DK, Evans R, Eyssade C, Ferguson DD, Hill S, Hutchinson R, Ingall AH, Kingston LP, Martin I, Martin BP, Mohammed RT, Murray C, Perry MW, Reynolds RH, Thorne PV, Wilkinson DJ, Withnall J. Guile SD, et al. Among authors: davis am. Bioorg Med Chem Lett. 2006 Apr 15;16(8):2260-5. doi: 10.1016/j.bmcl.2006.01.024. Epub 2006 Feb 7. Bioorg Med Chem Lett. 2006. PMID: 16455256
Accelerating the process of drug discovery.
Davis AM, Dixon J, Logan CJ, Payling DW. Davis AM, et al. Ernst Schering Res Found Workshop. 2002;(37):1-32. doi: 10.1007/978-3-662-04383-7_1. Ernst Schering Res Found Workshop. 2002. PMID: 11975191 Review. No abstract available.
Components of successful lead generation.
Davis AM, Keeling DJ, Steele J, Tomkinson NP, Tinker AC. Davis AM, et al. Curr Top Med Chem. 2005;5(4):421-39. doi: 10.2174/1568026053828411. Curr Top Med Chem. 2005. PMID: 15892684 Review.
844 results