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Page 1
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 1. Discovery of a novel series of potent antihyperglycemic and antihyperlipidemic agents.
Henke BR, Blanchard SG, Brackeen MF, Brown KK, Cobb JE, Collins JL, Harrington WW Jr, Hashim MA, Hull-Ryde EA, Kaldor I, Kliewer SA, Lake DH, Leesnitzer LM, Lehmann JM, Lenhard JM, Orband-Miller LA, Miller JF, Mook RA Jr, Noble SA, Oliver W Jr, Parks DJ, Plunket KD, Szewczyk JR, Willson TM. Henke BR, et al. Among authors: parks dj. J Med Chem. 1998 Dec 3;41(25):5020-36. doi: 10.1021/jm9804127. J Med Chem. 1998. PMID: 9836620
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 2. Structure-activity relationship and optimization of the phenyl alkyl ether moiety.
Collins JL, Blanchard SG, Boswell GE, Charifson PS, Cobb JE, Henke BR, Hull-Ryde EA, Kazmierski WM, Lake DH, Leesnitzer LM, Lehmann J, Lenhard JM, Orband-Miller LA, Gray-Nunez Y, Parks DJ, Plunkett KD, Tong WQ. Collins JL, et al. Among authors: parks dj. J Med Chem. 1998 Dec 3;41(25):5037-54. doi: 10.1021/jm980413z. J Med Chem. 1998. PMID: 9836621
N-(2-Benzoylphenyl)-L-tyrosine PPARgamma agonists. 3. Structure-activity relationship and optimization of the N-aryl substituent.
Cobb JE, Blanchard SG, Boswell EG, Brown KK, Charifson PS, Cooper JP, Collins JL, Dezube M, Henke BR, Hull-Ryde EA, Lake DH, Lenhard JM, Oliver W Jr, Oplinger J, Pentti M, Parks DJ, Plunket KD, Tong WQ. Cobb JE, et al. Among authors: parks dj. J Med Chem. 1998 Dec 3;41(25):5055-69. doi: 10.1021/jm980414r. J Med Chem. 1998. PMID: 9836622
A peroxisome proliferator-activated receptor gamma ligand inhibits adipocyte differentiation.
Oberfield JL, Collins JL, Holmes CP, Goreham DM, Cooper JP, Cobb JE, Lenhard JM, Hull-Ryde EA, Mohr CP, Blanchard SG, Parks DJ, Moore LB, Lehmann JM, Plunket K, Miller AB, Milburn MV, Kliewer SA, Willson TM. Oberfield JL, et al. Among authors: parks dj. Proc Natl Acad Sci U S A. 1999 May 25;96(11):6102-6. doi: 10.1073/pnas.96.11.6102. Proc Natl Acad Sci U S A. 1999. PMID: 10339548 Free PMC article.
A novel N-aryl tyrosine activator of peroxisome proliferator-activated receptor-gamma reverses the diabetic phenotype of the Zucker diabetic fatty rat.
Brown KK, Henke BR, Blanchard SG, Cobb JE, Mook R, Kaldor I, Kliewer SA, Lehmann JM, Lenhard JM, Harrington WW, Novak PJ, Faison W, Binz JG, Hashim MA, Oliver WO, Brown HR, Parks DJ, Plunket KD, Tong WQ, Menius JA, Adkison K, Noble SA, Willson TM. Brown KK, et al. Among authors: parks dj. Diabetes. 1999 Jul;48(7):1415-24. doi: 10.2337/diabetes.48.7.1415. Diabetes. 1999. PMID: 10389847
Identification of a chemical tool for the orphan nuclear receptor FXR.
Maloney PR, Parks DJ, Haffner CD, Fivush AM, Chandra G, Plunket KD, Creech KL, Moore LB, Wilson JG, Lewis MC, Jones SA, Willson TM. Maloney PR, et al. Among authors: parks dj. J Med Chem. 2000 Aug 10;43(16):2971-4. doi: 10.1021/jm0002127. J Med Chem. 2000. PMID: 10956205 No abstract available.
Functional consequences of cysteine modification in the ligand binding sites of peroxisome proliferator activated receptors by GW9662.
Leesnitzer LM, Parks DJ, Bledsoe RK, Cobb JE, Collins JL, Consler TG, Davis RG, Hull-Ryde EA, Lenhard JM, Patel L, Plunket KD, Shenk JL, Stimmel JB, Therapontos C, Willson TM, Blanchard SG. Leesnitzer LM, et al. Among authors: parks dj. Biochemistry. 2002 May 28;41(21):6640-50. doi: 10.1021/bi0159581. Biochemistry. 2002. PMID: 12022867
77 results