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314 results

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Page 1
Interaction of a novel GDP exchange inhibitor with the Ras protein.
Ganguly AK, Wang YS, Pramanik BN, Doll RJ, Snow ME, Taveras AG, Remiszewski S, Cesarz D, del Rosario J, Vibulbhan B, Brown JE, Kirschmeier P, Huang EC, Heimark L, Tsarbopoulos A, Girijavallabhan VM, Aust RM, Brown EL, DeLisle DM, Fuhrman SA, Hendrickson TF, Kissinger CR, Love RA, Sisson WA, Webber SE, et al. Ganguly AK, et al. Among authors: brown el, brown je. Biochemistry. 1998 Nov 10;37(45):15631-7. doi: 10.1021/bi9805691. Biochemistry. 1998. PMID: 9843367
Tripeptide aldehyde inhibitors of human rhinovirus 3C protease: design, synthesis, biological evaluation, and cocrystal structure solution of P1 glutamine isosteric replacements.
Webber SE, Okano K, Little TL, Reich SH, Xin Y, Fuhrman SA, Matthews DA, Love RA, Hendrickson TF, Patick AK, Meador JW 3rd, Ferre RA, Brown EL, Ford CE, Binford SL, Worland ST. Webber SE, et al. Among authors: brown el. J Med Chem. 1998 Jul 16;41(15):2786-805. doi: 10.1021/jm980071x. J Med Chem. 1998. PMID: 9667969
Structure-assisted design of mechanism-based irreversible inhibitors of human rhinovirus 3C protease with potent antiviral activity against multiple rhinovirus serotypes.
Matthews DA, Dragovich PS, Webber SE, Fuhrman SA, Patick AK, Zalman LS, Hendrickson TF, Love RA, Prins TJ, Marakovits JT, Zhou R, Tikhe J, Ford CE, Meador JW, Ferre RA, Brown EL, Binford SL, Brothers MA, DeLisle DM, Worland ST. Matthews DA, et al. Among authors: brown el. Proc Natl Acad Sci U S A. 1999 Sep 28;96(20):11000-7. doi: 10.1073/pnas.96.20.11000. Proc Natl Acad Sci U S A. 1999. PMID: 10500114 Free PMC article.
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 1. Michael acceptor structure-activity studies.
Dragovich PS, Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Reich SH, Prins TJ, Marakovits JT, Littlefield ES, Zhou R, Tikhe J, Ford CE, Wallace MB, Meador JW 3rd, Ferre RA, Brown EL, Binford SL, Harr JE, DeLisle DM, Worland ST. Dragovich PS, et al. Among authors: brown el. J Med Chem. 1998 Jul 16;41(15):2806-18. doi: 10.1021/jm980068d. J Med Chem. 1998. PMID: 9667970
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 2. Peptide structure-activity studies.
Dragovich PS, Webber SE, Babine RE, Fuhrman SA, Patick AK, Matthews DA, Reich SH, Marakovits JT, Prins TJ, Zhou R, Tikhe J, Littlefield ES, Bleckman TM, Wallace MB, Little TL, Ford CE, Meador JW 3rd, Ferre RA, Brown EL, Binford SL, DeLisle DM, Worland ST. Dragovich PS, et al. Among authors: brown el. J Med Chem. 1998 Jul 16;41(15):2819-34. doi: 10.1021/jm9800696. J Med Chem. 1998. PMID: 9667971
Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 4. Incorporation of P1 lactam moieties as L-glutamine replacements.
Dragovich PS, Prins TJ, Zhou R, Webber SE, Marakovits JT, Fuhrman SA, Patick AK, Matthews DA, Lee CA, Ford CE, Burke BJ, Rejto PA, Hendrickson TF, Tuntland T, Brown EL, Meador JW 3rd, Ferre RA, Harr JE, Kosa MB, Worland ST. Dragovich PS, et al. Among authors: brown el. J Med Chem. 1999 Apr 8;42(7):1213-24. doi: 10.1021/jm9805384. J Med Chem. 1999. PMID: 10197965
Structure-based design of irreversible, tripeptidyl human rhinovirus 3C protease inhibitors containing N-methyl amino acids.
Dragovich PS, Webber SE, Prins TJ, Zhou R, Marakovits JT, Tikhe JG, Fuhrman SA, Patick AK, Matthews DA, Ford CE, Brown EL, Binford SL, Meador JW 3rd, Ferre RA, Worland ST. Dragovich PS, et al. Among authors: brown el. Bioorg Med Chem Lett. 1999 Aug 2;9(15):2189-94. doi: 10.1016/s0960-894x(99)00368-6. Bioorg Med Chem Lett. 1999. PMID: 10465543
Structure-based design of ketone-containing, tripeptidyl human rhinovirus 3C protease inhibitors.
Dragovich PS, Zhou R, Webber SE, Prins TJ, Kwok AK, Okano K, Fuhrman SA, Zalman LS, Maldonado FC, Brown EL, Meador JW 3rd, Patick AK, Ford CE, Brothers MA, Binford SL, Matthews DA, Ferre RA, Worland ST. Dragovich PS, et al. Among authors: brown el. Bioorg Med Chem Lett. 2000 Jan 3;10(1):45-8. doi: 10.1016/s0960-894x(99)00587-9. Bioorg Med Chem Lett. 2000. PMID: 10636240
314 results