Rafferty JA - Search Results

1

Inactivation of O6-alkylguanine-DNA alkyltransferase. 1. Novel O6-(hetarylmethyl)guanines having basic rings in the side chain.

McElhinney RS, Donnelly DJ, McCormick JE, Kelly J, Watson AJ, Rafferty JA, Elder RH, Middleton MR, Willington MA, McMurry TB, Margison GP. McElhinney RS, et al. Among authors: rafferty ja. J Med Chem. 1998 Dec 17;41(26):5265-71. doi: 10.1021/jm9708644. J Med Chem. 1998. PMID: 9857094

2

Expression of a human O6-alkylguanine-DNA-alkyltransferase cDNA in human cells and transgenic mice.

Fan CY, Potter PM, Rafferty J, Watson AJ, Cawkwell L, Searle PF, O'Connor PJ, Margison GP. Fan CY, et al. Nucleic Acids Res. 1990 Oct 11;18(19):5723-7. doi: 10.1093/nar/18.19.5723. Nucleic Acids Res. 1990. PMID: 2216765 Free PMC article.

3

Cyclophosphamide decreases O6-alkylguanine-DNA alkyltransferase activity in peripheral lymphocytes of patients undergoing bone marrow transplantation.

Lee SM, Crowther D, Scarffe JH, Dougal M, Elder RH, Rafferty JA, Margison GP. Lee SM, et al. Among authors: rafferty ja. Br J Cancer. 1992 Aug;66(2):331-6. doi: 10.1038/bjc.1992.265. Br J Cancer. 1992. PMID: 1387001 Free PMC article.

4

C-terminally truncated human O6-alkylguanine-DNA alkyltransferase retains activity.

Elder RH, Tumelty J, Douglas KT, Margison GP, Rafferty JA. Elder RH, et al. Among authors: rafferty ja. Biochem J. 1992 Aug 1;285 ( Pt 3)(Pt 3):707-9. doi: 10.1042/bj2850707. Biochem J. 1992. PMID: 1497608 Free PMC article.

5

Tissue-specific expression and induction of human O6-alkylguanine-DNA alkyltransferase in transgenic mice.

Rafferty JA, Fan CY, Potter PM, Watson AJ, Cawkwell L, O'Connor PJ, Margison GP. Rafferty JA, et al. Mol Carcinog. 1992;6(1):26-31. doi: 10.1002/mc.2940060106. Mol Carcinog. 1992. PMID: 1503642

6

Isolation and partial characterization of murine O6-alkylguanine-DNA-alkyltransferase: comparative sequence and structural properties.

Santibanez-Koref M, Elder RH, Fan CY, Cawkwell L, McKie JH, Douglas KT, Margison GP, Rafferty JA. Santibanez-Koref M, et al. Among authors: rafferty ja. Mol Carcinog. 1992;5(2):161-9. doi: 10.1002/mc.2940050212. Mol Carcinog. 1992. PMID: 1554415

7

Isolation and partial characterisation of a Chinese hamster O6-alkylguanine-DNA alkyltransferase cDNA.

Rafferty JA, Elder RH, Watson AJ, Cawkwell L, Potter PM, Margison GP. Rafferty JA, et al. Nucleic Acids Res. 1992 Apr 25;20(8):1891-5. doi: 10.1093/nar/20.8.1891. Nucleic Acids Res. 1992. PMID: 1579490 Free PMC article.

8

Isolation and cDNA cloning of a rat O6-alkylguanine-DNA-alkyltransferase gene, molecular analysis of expression in rat liver.

Potter PM, Rafferty JA, Cawkwell L, Wilkinson MC, Cooper DP, O'Connor PJ, Margison GP. Potter PM, et al. Among authors: rafferty ja. Carcinogenesis. 1991 Apr;12(4):727-33. doi: 10.1093/carcin/12.4.727. Carcinogenesis. 1991. PMID: 2013136

9

O6-benzylguanine increases the sensitivity of human primary bone marrow cells to the cytotoxic effects of temozolomide.

Fairbairn LJ, Watson AJ, Rafferty JA, Elder RH, Margison GP. Fairbairn LJ, et al. Among authors: rafferty ja. Exp Hematol. 1995 Feb;23(2):112-6. Exp Hematol. 1995. PMID: 7828668

10

Site-directed mutagenesis of glutamic acid 172 to glutamine completely inactivated human O6-alkylguanine-DNA-alkyltransferase.

Rafferty JA, Tumelty J, Skorvaga M, Elder RH, Margison GP, Douglas KT. Rafferty JA, et al. Biochem Biophys Res Commun. 1994 Feb 28;199(1):285-91. doi: 10.1006/bbrc.1994.1226. Biochem Biophys Res Commun. 1994. PMID: 8123025

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