Takai S - Search Results

1

Peptidyl human heart chymase inhibitors. 2. Discovery of highly selective difluoromethylene ketone derivatives with Glu at P3 site.

Eda M, Ashimori A, Akahoshi F, Yoshimura T, Inoue Y, Fukaya C, Nakajima M, Fukuyama H, Imada T, Takai S, Shiota N, Miyazaki M, Nakamura N. Eda M, et al. Among authors: takai s. Bioorg Med Chem Lett. 1998 Apr 21;8(8):919-24. doi: 10.1016/s0960-894x(98)00132-2. Bioorg Med Chem Lett. 1998. PMID: 9871512

2

Peptidyl human heart chymase inhibitors. 1. Synthesis and inhibitory activity of difluoromethylene ketone derivatives bearing P' binding subsites.

Eda M, Ashimori A, Akahoshi F, Yoshimura T, Inoue Y, Fukaya C, Nakajima M, Fukuyama H, Imada T, Takai S, Shiota N, Miyazaki M, Nakamura N. Eda M, et al. Among authors: takai s. Bioorg Med Chem Lett. 1998 Apr 21;8(8):913-8. doi: 10.1016/s0960-894x(98)00131-0. Bioorg Med Chem Lett. 1998. PMID: 9871511

3

Substituted 3-(phenylsulfonyl)-1-phenylimidazolidine-2,4-dione derivatives as novel nonpeptide inhibitors of human heart chymase.

Niwata S, Fukami H, Sumida M, Ito A, Kakutani S, Saitoh M, Suzuki K, Imoto M, Shibata H, Imajo S, Kiso Y, Tanaka T, Nakazato H, Ishihara T, Takai S, Yamamoto D, Shiota N, Miyazaki M, Okunishi H, Kinoshita A, Urata H, Arakawa K. Niwata S, et al. Among authors: takai s. J Med Chem. 1997 Jul 4;40(14):2156-63. doi: 10.1021/jm960793t. J Med Chem. 1997. PMID: 9216834

4

Functional role of chymase in angiotensin II formation in human vascular tissue.

Takai S, Shiota N, Jin D, Miyazaki M. Takai S, et al. J Cardiovasc Pharmacol. 1998 Nov;32(5):826-33. doi: 10.1097/00005344-199811000-00020. J Cardiovasc Pharmacol. 1998. PMID: 9821858

5

Chymase processes big-endothelin-2 to endothelin-2-(1-31) that induces contractile responses in the isolated monkey trachea.

Takai S, Shiota N, Jin D, Miyazaki M. Takai S, et al. Eur J Pharmacol. 1998 Oct 9;358(3):229-33. doi: 10.1016/s0014-2999(98)00622-0. Eur J Pharmacol. 1998. PMID: 9822889

6

Lack of effect of carbohydrate depletion on some properties of human mast cell chymase.

Takao K, Takai S, Shiota N, Song K, Nishimura K, Ishihara T, Miyazaki M. Takao K, et al. Among authors: takai s. Biochim Biophys Acta. 1999 Mar 14;1427(1):74-81. doi: 10.1016/s0304-4165(99)00002-1. Biochim Biophys Acta. 1999. PMID: 10082988

7

Effects of daphnodorin A, daphnodorin B and daphnodorin C on human chymase-dependent angiotensin II formation.

Takai S, Sakaguchi M, Jin D, Baba K, Miyazaki M. Takai S, et al. Life Sci. 1999;64(21):1889-96. doi: 10.1016/s0024-3205(99)00135-6. Life Sci. 1999. PMID: 10353587

8

[Role of angiotensin II-forming enzymes, angiotensin-converting enzyme and chymase].

Takai S, Miyazaki M. Takai S, et al. Nihon Rinsho. 1999 May;57(5):1078-83. Nihon Rinsho. 1999. PMID: 10361438 Review. Japanese.

9

Chymase-dependent angiotensin II formation in human vascular tissue.

Takai S, Jin D, Sakaguchi M, Miyazaki M. Takai S, et al. Circulation. 1999 Aug 10;100(6):654-8. doi: 10.1161/01.cir.100.6.654. Circulation. 1999. PMID: 10441104

10

[Pathophysiological roles of chymase and effects of chymase inhibitor].

Takai S, Jin D, Miyazaki M. Takai S, et al. Nihon Yakurigaku Zasshi. 1999 Oct;114 Suppl 1:41P-47P. doi: 10.1254/fpj.114.supplement_41. Nihon Yakurigaku Zasshi. 1999. PMID: 10629853 Review. Japanese.

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