Ruell JA - Search Results

1

Synthesis of a cosalane analog with an extended polyanionic pharmacophore conferring enhanced potency as an anti-HIV agent.

Cushman M, Insaf S, Ruell JA, Schaeffer CA, Rice WG. Cushman M, et al. Among authors: ruell ja. Bioorg Med Chem Lett. 1998 Apr 7;8(7):833-6. doi: 10.1016/s0960-894x(98)00121-8. Bioorg Med Chem Lett. 1998. PMID: 9871550

2

Extension of the polyanionic cosalane pharmacophore as a strategy for increasing anti-HIV potency.

Cushman M, Insaf S, Paul G, Ruell JA, De Clercq E, Schols D, Pannecouque C, Witvrouw M, Schaeffer CA, Turpin JA, Williamson K, Rice WG. Cushman M, et al. Among authors: ruell ja. J Med Chem. 1999 May 20;42(10):1767-77. doi: 10.1021/jm980727m. J Med Chem. 1999. PMID: 10346929

3

New alkenyldiarylmethanes with enhanced potencies as anti-HIV agents which act as non-nucleoside reverse transcriptase inhibitors.

Cushman M, Casimiro-Garcia A, Hejchman E, Ruell JA, Huang M, Schaeffer CA, Williamson K, Rice WG, Buckheit RW Jr. Cushman M, et al. Among authors: ruell ja. J Med Chem. 1998 Jun 4;41(12):2076-89. doi: 10.1021/jm9800595. J Med Chem. 1998. PMID: 9622549

4

Molecular similarity from atomic electrostatic multipole comparisons. Application to anti-HIV drugs.

Burgess EM, Ruell JA, Zalkow LH, Haugwitz RD. Burgess EM, et al. Among authors: ruell ja. J Med Chem. 1995 May 12;38(10):1635-40. doi: 10.1021/jm00010a007. J Med Chem. 1995. PMID: 7752188

5

Ionization, lipophilicity, and molecular modeling to investigate permeability and other biological properties of amlodipine.

Caron G, Ermondi G, Damiano A, Novaroli L, Tsinman O, Ruell JA, Avdeef A. Caron G, et al. Among authors: ruell ja. Bioorg Med Chem. 2004 Dec 1;12(23):6107-18. doi: 10.1016/j.bmc.2004.09.004. Bioorg Med Chem. 2004. PMID: 15519156

6

Acid-base cosolvent method for determining aqueous permeability of amiodarone, itraconazole, tamoxifen, terfenadine and other very insoluble molecules.

Ruell JA, Tsinman O, Avdeef A. Ruell JA, et al. Chem Pharm Bull (Tokyo). 2004 May;52(5):561-5. doi: 10.1248/cpb.52.561. Chem Pharm Bull (Tokyo). 2004. PMID: 15133208 Free article.

7

PAMPA--a drug absorption in vitro model. 5. Unstirred water layer in iso-pH mapping assays and pKa(flux)--optimized design (pOD-PAMPA).

Ruell JA, Tsinman KL, Avdeef A. Ruell JA, et al. Eur J Pharm Sci. 2003 Dec;20(4-5):393-402. doi: 10.1016/j.ejps.2003.08.006. Eur J Pharm Sci. 2003. PMID: 14659483

8

PAMPA--a drug absorption in vitro model 7. Comparing rat in situ, Caco-2, and PAMPA permeability of fluoroquinolones.

Bermejo M, Avdeef A, Ruiz A, Nalda R, Ruell JA, Tsinman O, González I, Fernández C, Sánchez G, Garrigues TM, Merino V. Bermejo M, et al. Among authors: ruell ja. Eur J Pharm Sci. 2004 Mar;21(4):429-41. doi: 10.1016/j.ejps.2003.10.009. Eur J Pharm Sci. 2004. PMID: 14998573

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