Lynch RJ - Search Results

1

Nonpeptide glycoprotein IIb/IIIa inhibitors: substituted quinazolinediones and quinazolinones as potent fibrinogen receptor antagonists.

Liverton NJ, Armstrong DJ, Claremon DA, Remy DC, Baldwin JJ, Lynch RJ, Zhang G, Gould RJ. Liverton NJ, et al. Among authors: lynch rj. Bioorg Med Chem Lett. 1998 Mar 3;8(5):483-6. doi: 10.1016/s0960-894x(98)00047-x. Bioorg Med Chem Lett. 1998. PMID: 9871603

2

Non-peptide fibrinogen receptor antagonists. 2. Optimization of a tyrosine template as a mimic for Arg-Gly-Asp.

Egbertson MS, Chang CT, Duggan ME, Gould RJ, Halczenko W, Hartman GD, Laswell WL, Lynch JJ Jr, Lynch RJ, Manno PD, et al. Egbertson MS, et al. Among authors: lynch jj jr, lynch rj. J Med Chem. 1994 Aug 5;37(16):2537-51. doi: 10.1021/jm00042a007. J Med Chem. 1994. PMID: 8057299

3

Non-peptide glycoprotein IIb/IIIa antagonists. 11. Design and in vivo evaluation of 3,4-dihydro-1 (1H)-isoquinolinone-based antagonists and ethyl ester prodrugs.

Hutchinson JH, Cook JJ, Brashear KM, Breslin MJ, Glass JD, Gould RJ, Halczenko W, Holahan MA, Lynch RJ, Sitko GR, Stranieri MT, Hartman GD. Hutchinson JH, et al. Among authors: lynch rj. J Med Chem. 1996 Nov 8;39(23):4583-91. doi: 10.1021/jm9604787. J Med Chem. 1996. PMID: 8917647

4

Non-peptide glycoprotein IIb/IIIa inhibitors. 17. Design and synthesis of orally active, long-acting non-peptide fibrinogen receptor antagonists.

Askew BC, Bednar RA, Bednar B, Claremon DA, Cook JJ, McIntyre CJ, Hunt CA, Gould RJ, Lynch RJ, Lynch JJ Jr, Gaul SL, Stranieri MT, Sitko GR, Holahan MA, Glass JD, Hamill T, Gorham LM, Prueksaritanont T, Baldwin JJ, Hartman GD. Askew BC, et al. Among authors: lynch jj jr, lynch rj. J Med Chem. 1997 Jun 6;40(12):1779-88. doi: 10.1021/jm9608117. J Med Chem. 1997. PMID: 9191954

5

Nonpeptide glycoprotein IIB/IIIA inhibitors. 19. A new design paradigm employing linearly minimized, centrally constrained, exosite inhibitors.

Hartman GD, Duggan ME, Hoffman WF, Meissner RJ, Perkins JJ, Zartman AE, Naylor-Olsen AM, Cook JJ, Glass JD, Lynch RJ, Zhang G, Gould RJ. Hartman GD, et al. Among authors: lynch rj. Bioorg Med Chem Lett. 1999 Mar 22;9(6):863-8. doi: 10.1016/s0960-894x(99)00104-3. Bioorg Med Chem Lett. 1999. PMID: 10206551

6

Non-peptide GPIIb/IIIa inhibitors. 20. Centrally constrained thienothiophene alpha-sulfonamides are potent, long acting in vivo inhibitors of platelet aggregation.

Egbertson MS, Cook JJ, Bednar B, Prugh JD, Bednar RA, Gaul SL, Gould RJ, Hartman GD, Homnick CF, Holahan MA, Libby LA, Lynch JJ Jr, Lynch RJ, Sitko GR, Stranieri MT, Vassallo LM. Egbertson MS, et al. Among authors: lynch jj jr, lynch rj. J Med Chem. 1999 Jul 1;42(13):2409-21. doi: 10.1021/jm980722p. J Med Chem. 1999. PMID: 10395482

7

Non-peptide fibrinogen receptor antagonists. 1. Discovery and design of exosite inhibitors.

Hartman GD, Egbertson MS, Halczenko W, Laswell WL, Duggan ME, Smith RL, Naylor AM, Manno PD, Lynch RJ, Zhang G, et al. Hartman GD, et al. Among authors: lynch rj. J Med Chem. 1992 Nov 27;35(24):4640-2. doi: 10.1021/jm00102a020. J Med Chem. 1992. PMID: 1469694 No abstract available.

8

Nonpeptide glycoprotein IIb/IIIa inhibitors. 5. Antithrombotic effects of MK-0383.

Lynch JJ Jr, Cook JJ, Sitko GR, Holahan MA, Ramjit DR, Mellott MJ, Stranieri MT, Stabilito II, Zhang G, Lynch RJ, et al. Lynch JJ Jr, et al. Among authors: lynch rj. J Pharmacol Exp Ther. 1995 Jan;272(1):20-32. J Pharmacol Exp Ther. 1995. PMID: 7815334

9

Non-peptide alpha(v)beta(3) antagonists. Part 4: potent and orally bioavailable chain-shortened RGD mimetics.

Coleman PJ, Askew BC, Hutchinson JH, Whitman DB, Perkins JJ, Hartman GD, Rodan GA, Leu CT, Prueksaritanont T, Fernandez-Metzler C, Merkle KM, Lynch R, Lynch JJ, Rodan SB, Duggan ME. Coleman PJ, et al. Bioorg Med Chem Lett. 2002 Sep 2;12(17):2463-5. doi: 10.1016/s0960-894x(02)00396-7. Bioorg Med Chem Lett. 2002. PMID: 12161158

10

Non-peptide alpha(v)beta(3) antagonists. Part 3: identification of potent RGD mimetics incorporating novel beta-amino acids as aspartic acid replacements.

Coleman PJ, Brashear KM, Hunt CA, Hoffman WF, Hutchinson JH, Breslin MJ, McVean CA, Askew BC, Hartman GD, Rodan SB, Rodan GA, Leu CT, Prueksaritanont T, Fernandez-Metzler C, Ma B, Libby LA, Merkle KM, Stump GL, Wallace AA, Lynch JJ, Lynch R, Duggan ME. Coleman PJ, et al. Bioorg Med Chem Lett. 2002 Jan 7;12(1):31-4. doi: 10.1016/s0960-894x(01)00666-7. Bioorg Med Chem Lett. 2002. PMID: 11738567

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