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Page 1
Synthesis and SAR of diazepine and thiazepine TACE and MMP inhibitors.
Zask A, Kaplan J, Du X, MacEwan G, Sandanayaka V, Eudy N, Levin J, Jin G, Xu J, Cummons T, Barone D, Ayral-Kaloustian S, Skotnicki J. Zask A, et al. Bioorg Med Chem Lett. 2005 Mar 15;15(6):1641-5. doi: 10.1016/j.bmcl.2005.01.053. Bioorg Med Chem Lett. 2005. PMID: 15745814
Benzodiazepine inhibitors of the MMPs and TACE.
Nelson FC, Delos Santos E, Levin JI, Chen JM, Skotnicki JS, DiJoseph JF, Sharr MA, Sung A, Killar LM, Cowling R, Jin G, Roth CE, Albright JD. Nelson FC, et al. Among authors: levin ji. Bioorg Med Chem Lett. 2002 Oct 21;12(20):2867-70. doi: 10.1016/s0960-894x(02)00633-9. Bioorg Med Chem Lett. 2002. PMID: 12270165
Synthesis and structure-activity relationship of N-substituted 4-arylsulfonylpiperidine-4-hydroxamic acids as novel, orally active matrix metalloproteinase inhibitors for the treatment of osteoarthritis.
Aranapakam V, Davis JM, Grosu GT, Baker J, Ellingboe J, Zask A, Levin JI, Sandanayaka VP, Du M, Skotnicki JS, DiJoseph JF, Sung A, Sharr MA, Killar LM, Walter T, Jin G, Cowling R, Tillett J, Zhao W, McDevitt J, Xu ZB. Aranapakam V, et al. Among authors: levin ji. J Med Chem. 2003 Jun 5;46(12):2376-96. doi: 10.1021/jm0205550. J Med Chem. 2003. PMID: 12773042
Synthesis and structure-activity relationships of 4-alkynyloxy phenyl sulfanyl, sulfinyl, and sulfonyl alkyl hydroxamates as tumor necrosis factor-alpha converting enzyme and matrix metalloproteinase inhibitors.
Venkatesan AM, Davis JM, Grosu GT, Baker J, Zask A, Levin JI, Ellingboe J, Skotnicki JS, Dijoseph JF, Sung A, Jin G, Xu W, McCarthy DJ, Barone D. Venkatesan AM, et al. Among authors: levin ji. J Med Chem. 2004 Dec 2;47(25):6255-69. doi: 10.1021/jm040086x. J Med Chem. 2004. PMID: 15566296
Identification of potent and selective MMP-13 inhibitors.
Wu J, Rush TS 3rd, Hotchandani R, Du X, Geck M, Collins E, Xu ZB, Skotnicki J, Levin JI, Lovering FE. Wu J, et al. Among authors: levin ji. Bioorg Med Chem Lett. 2005 Sep 15;15(18):4105-9. doi: 10.1016/j.bmcl.2005.06.019. Bioorg Med Chem Lett. 2005. PMID: 16005220
Synthesis and SAR of highly selective MMP-13 inhibitors.
Li J, Rush TS 3rd, Li W, DeVincentis D, Du X, Hu Y, Thomason JR, Xiang JS, Skotnicki JS, Tam S, Cunningham KM, Chockalingam PS, Morris EA, Levin JI. Li J, et al. Among authors: levin ji. Bioorg Med Chem Lett. 2005 Nov 15;15(22):4961-6. doi: 10.1016/j.bmcl.2005.08.001. Bioorg Med Chem Lett. 2005. PMID: 16153831
59 results