Howard PW - Search Results

1

Design, synthesis and biological activity of a pyrrolo [2,1-c][1,4]benzodiazepine (PBD)-distamycin hybrid.

Baraldi PG, Cacciari B, Guiotto A, Leoni A, Romagnoli R, Spalluto G, Mongelli N, Howard PW, Thurston DE, Bianchi N, Gambari R. Baraldi PG, et al. Among authors: howard pw. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3019-24. doi: 10.1016/S0960-894X(98)00544-7. Bioorg Med Chem Lett. 1998. PMID: 9873668

2

Synthesis and biological evaluation of an N10-Psec substituted pyrrolo[2,1-c][1,4]benzodiazepine prodrug.

Berry JM, Howard PW, Kelland LR, Thurston DE. Berry JM, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2002 May 20;12(10):1413-6. doi: 10.1016/s0960-894x(02)00150-6. Bioorg Med Chem Lett. 2002. PMID: 11992788

3

Synthesis of the first examples of A-C8/C-C2 amide-Linked pyrrolo[2,1-c][1,4]benzodiazepine dimers.

Gregson SJ, Howard PW, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2003 Jul 21;13(14):2277-80. doi: 10.1016/s0960-894x(03)00436-0. Bioorg Med Chem Lett. 2003. PMID: 12824017

4

Synthesis and biological evaluation of pyrrolo[2,1-c][1,4]benzodiazepine (PBD) C8 cyclic amine conjugates.

Masterson LA, Croker SJ, Jenkins TC, Howard PW, Thurston DE. Masterson LA, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2004 Feb 23;14(4):901-4. doi: 10.1016/j.bmcl.2003.12.017. Bioorg Med Chem Lett. 2004. PMID: 15012990

5

Synthesis of a novel C2-aryl pyrrolo[2,1-c][1,4]benzodiazepine-5,11-dione library: effect of C2-aryl substitution on cytotoxicity and non-covalent DNA binding.

Antonow D, Jenkins TC, Howard PW, Thurston DE. Antonow D, et al. Among authors: howard pw. Bioorg Med Chem. 2007 Apr 15;15(8):3041-53. doi: 10.1016/j.bmc.2007.01.054. Epub 2007 Feb 2. Bioorg Med Chem. 2007. PMID: 17317191

6

Synthesis of novel C7-aryl substituted pyrrolo[2,1-c][1,4]benzodiazepines (PBDs) via pro-N10-Troc protection and Suzuki coupling.

Guiotto A, Howard PW, Baraldi PG, Thurston DE. Guiotto A, et al. Among authors: howard pw. Bioorg Med Chem Lett. 1998 Nov 3;8(21):3017-8. doi: 10.1016/S0960-894X(97)10083-X. Bioorg Med Chem Lett. 1998. PMID: 9873667

7

Effect of A-ring modifications on the DNA-binding behavior and cytotoxicity of pyrrolo[2,1-c][1,4]benzodiazepines.

Thurston DE, Bose DS, Howard PW, Jenkins TC, Leoni A, Baraldi PG, Guiotto A, Cacciari B, Kelland LR, Foloppe MP, Rault S. Thurston DE, et al. Among authors: howard pw. J Med Chem. 1999 Jun 3;42(11):1951-64. doi: 10.1021/jm981117p. J Med Chem. 1999. PMID: 10354403

8

Synthesis, in vitro antiproliferative activity, and DNA-binding properties of hybrid molecules containing pyrrolo[2,1-c][1, 4]benzodiazepine and minor-groove-binding oligopyrrole carriers.

Baraldi PG, Balboni G, Cacciari B, Guiotto A, Manfredini S, Romagnoli R, Spalluto G, Thurston DE, Howard PW, Bianchi N, Rutigliano C, Mischiati C, Gambari R. Baraldi PG, et al. Among authors: howard pw. J Med Chem. 1999 Dec 16;42(25):5131-41. doi: 10.1021/jm991033w. J Med Chem. 1999. PMID: 10602698

9

Synthesis of the first example of a C2-C3/C2'-C3'-endo unsaturated pyrrolo[2,1-c][1,4]benzodiazepine dimer.

Gregson SJ, Howard PW, Corcoran KE, Jenkins TC, Kelland LR, Thurston DE. Gregson SJ, et al. Among authors: howard pw. Bioorg Med Chem Lett. 2001 Nov 5;11(21):2859-62. doi: 10.1016/s0960-894x(01)00560-1. Bioorg Med Chem Lett. 2001. PMID: 11597416

10

Linker length modulates DNA cross-linking reactivity and cytotoxic potency of C8/C8' ether-linked C2-exo-unsaturated pyrrolo[2,1-c][1,4]benzodiazepine (PBD) dimers.

Gregson SJ, Howard PW, Gullick DR, Hamaguchi A, Corcoran KE, Brooks NA, Hartley JA, Jenkins TC, Patel S, Guille MJ, Thurston DE. Gregson SJ, et al. Among authors: howard pw. J Med Chem. 2004 Feb 26;47(5):1161-74. doi: 10.1021/jm030897l. J Med Chem. 2004. PMID: 14971896

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