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The stress kinase mitogen-activated protein kinase kinase (MKK)7 is a negative regulator of antigen receptor and growth factor receptor-induced proliferation in hematopoietic cells.
Sasaki T, Wada T, Kishimoto H, Irie-Sasaki J, Matsumoto G, Goto T, Yao Z, Wakeham A, Mak TW, Suzuki A, Cho SK, Zuniga-Pflucker JC, Oliveira-dos-Santos AJ, Katada T, Nishina H, Penninger JM. Sasaki T, et al. J Exp Med. 2001 Sep 17;194(6):757-68. doi: 10.1084/jem.194.6.757. J Exp Med. 2001. PMID: 11560992 Free PMC article.
Impaired synergistic activation of stress-activated protein kinase SAPK/JNK in mouse embryonic stem cells lacking SEK1/MKK4: different contribution of SEK2/MKK7 isoforms to the synergistic activation.
Wada T, Nakagawa K, Watanabe T, Nishitai G, Seo J, Kishimoto H, Kitagawa D, Sasaki T, Penninger JM, Nishina H, Katada T. Wada T, et al. Among authors: sasaki t. J Biol Chem. 2001 Aug 17;276(33):30892-7. doi: 10.1074/jbc.M011780200. Epub 2001 Jun 19. J Biol Chem. 2001. PMID: 11418587 Free article.
TRAF6 deficiency results in osteopetrosis and defective interleukin-1, CD40, and LPS signaling.
Lomaga MA, Yeh WC, Sarosi I, Duncan GS, Furlonger C, Ho A, Morony S, Capparelli C, Van G, Kaufman S, van der Heiden A, Itie A, Wakeham A, Khoo W, Sasaki T, Cao Z, Penninger JM, Paige CJ, Lacey DL, Dunstan CR, Boyle WJ, Goeddel DV, Mak TW. Lomaga MA, et al. Among authors: sasaki t. Genes Dev. 1999 Apr 15;13(8):1015-24. doi: 10.1101/gad.13.8.1015. Genes Dev. 1999. PMID: 10215628 Free PMC article.
The oncogene product Vav is a crucial regulator of primary cytotoxic T cell responses but has no apparent role in CD28-mediated co-stimulation.
Penninger JM, Fischer KD, Sasaki T, Kozieradzki I, Le J, Tedford K, Bachmaier K, Ohashi PS, Bachmann MF. Penninger JM, et al. Among authors: sasaki t. Eur J Immunol. 1999 May;29(5):1709-18. doi: 10.1002/(SICI)1521-4141(199905)29:05<1709::AID-IMMU1709>3.0.CO;2-O. Eur J Immunol. 1999. PMID: 10359126 Free article.
9,396 results