Guarente L - Search Results

1

Structure of HAP1-18-DNA implicates direct allosteric effect of protein-DNA interactions on transcriptional activation.

King DA, Zhang L, Guarente L, Marmorstein R. King DA, et al. Among authors: guarente l. Nat Struct Biol. 1999 Jan;6(1):22-7. doi: 10.1038/4893. Nat Struct Biol. 1999. PMID: 9886287

2

Structure of a HAP1-DNA complex reveals dramatically asymmetric DNA binding by a homodimeric protein.

King DA, Zhang L, Guarente L, Marmorstein R. King DA, et al. Among authors: guarente l. Nat Struct Biol. 1999 Jan;6(1):64-71. doi: 10.1038/4940. Nat Struct Biol. 1999. PMID: 9886294

3

The yeast activator HAP1--a GAL4 family member--binds DNA in a directly repeated orientation.

Zhang L, Guarente L. Zhang L, et al. Among authors: guarente l. Genes Dev. 1994 Sep 1;8(17):2110-9. doi: 10.1101/gad.8.17.2110. Genes Dev. 1994. PMID: 7958882 Free article.

4

Evidence that TUP1/SSN6 has a positive effect on the activity of the yeast activator HAP1.

Zhang L, Guarente L. Zhang L, et al. Among authors: guarente l. Genetics. 1994 Mar;136(3):813-7. doi: 10.1093/genetics/136.3.813. Genetics. 1994. PMID: 8005436 Free PMC article.

5

HAP1 is nuclear but is bound to a cellular factor in the absence of heme.

Zhang L, Guarente L. Zhang L, et al. Among authors: guarente l. J Biol Chem. 1994 May 20;269(20):14643-7. J Biol Chem. 1994. PMID: 8182072 Free article.

6

The C6 zinc cluster dictates asymmetric binding by HAP1.

Zhang L, Guarente L. Zhang L, et al. Among authors: guarente l. EMBO J. 1996 Sep 2;15(17):4676-81. EMBO J. 1996. PMID: 8887558 Free PMC article.

7

Heme binds to a short sequence that serves a regulatory function in diverse proteins.

Zhang L, Guarente L. Zhang L, et al. Among authors: guarente l. EMBO J. 1995 Jan 16;14(2):313-20. doi: 10.1002/j.1460-2075.1995.tb07005.x. EMBO J. 1995. PMID: 7835342 Free PMC article.

8

Antibody-promoted dimerization bypasses the regulation of DNA binding by the heme domain of the yeast transcriptional activator HAP1.

Zhang L, Bermingham-McDonogh O, Turcotte B, Guarente L. Zhang L, et al. Among authors: guarente l. Proc Natl Acad Sci U S A. 1993 Apr 1;90(7):2851-5. doi: 10.1073/pnas.90.7.2851. Proc Natl Acad Sci U S A. 1993. PMID: 8464899 Free PMC article.

9

Mutations that alter transcriptional activation but not DNA binding in the zinc finger of yeast activator HAPI.

Kim KS, Guarente L. Kim KS, et al. Among authors: guarente l. Nature. 1989 Nov 9;342(6246):200-3. doi: 10.1038/342200a0. Nature. 1989. PMID: 2509943

10

The acidic transcriptional activation domains of herpes virus VP16 and yeast HAP4 have different co-factor requirements.

Wang L, Turcotte B, Guarente L, Berger SL. Wang L, et al. Among authors: guarente l. Gene. 1995 Jun 9;158(2):163-70. doi: 10.1016/0378-1119(95)00126-q. Gene. 1995. PMID: 7607537

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