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Amyloid-β accumulation in human astrocytes induces mitochondrial disruption and changed energy metabolism.
Zyśk M, Beretta C, Naia L, Dakhel A, Påvénius L, Brismar H, Lindskog M, Ankarcrona M, Erlandsson A. Zyśk M, et al. J Neuroinflammation. 2023 Feb 20;20(1):43. doi: 10.1186/s12974-023-02722-z. J Neuroinflammation. 2023. PMID: 36803838 Free PMC article.
BACKGROUND: Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of Alzheimer's disease (AD). Our previous studies demonstrate that inflammatory astrocytes accumulate large amounts of aggregated amyloid-b …
BACKGROUND: Astrocytes play a central role in maintaining brain energy metabolism, but are also tightly connected to the pathogenesis of Alz …
Continuous β-Amyloid CSF/PET Imbalance Model to Capture Alzheimer Disease Heterogeneity.
Mastenbroek SE, Sala A, Vállez García D, Shekari M, Salvadó G, Lorenzini L, Pieperhoff L, Wink AM, Lopes Alves I, Wolz R, Ritchie C, Boada M, Visser PJ, Bucci M, Farrar G, Hansson O, Nordberg AK, Ossenkoppele R, Barkhof F, Gispert JD, Rodriguez-Vieitez E, Collij LE; Alzheimer's Disease Neuroimaging Initiative on behalf of the AMYPAD consortium. Mastenbroek SE, et al. Neurology. 2024 Jul 9;103(1):e209419. doi: 10.1212/WNL.0000000000209419. Epub 2024 Jun 11. Neurology. 2024. PMID: 38862136 Free PMC article.
METHODS: Across 822 cognitively unimpaired (n = 261) and cognitively impaired (n = 561) Alzheimer's Disease Neuroimaging Initiative individuals (384 [46.7%] females, mean age 73.0 7.4 years), we fitted baseline CSF-Abeta(42) and global Abeta-PET to a hyperbolic regression …
METHODS: Across 822 cognitively unimpaired (n = 261) and cognitively impaired (n = 561) Alzheimer's Disease Neuroimaging Initiative i …
Endo-lysosomal proteins and ubiquitin CSF concentrations in Alzheimer's and Parkinson's disease.
Sjödin S, Brinkmalm G, Öhrfelt A, Parnetti L, Paciotti S, Hansson O, Hardy J, Blennow K, Zetterberg H, Brinkmalm A. Sjödin S, et al. Alzheimers Res Ther. 2019 Sep 14;11(1):82. doi: 10.1186/s13195-019-0533-9. Alzheimers Res Ther. 2019. PMID: 31521194 Free PMC article.
BACKGROUND: Increasing evidence implicates dysfunctional proteostasis and the involvement of the autophagic and endo-lysosomal system and the ubiquitin-proteasome system in neurodegenerative diseases. In Alzheimer's disease (AD), there is an accumulation of autophagic vacu …
BACKGROUND: Increasing evidence implicates dysfunctional proteostasis and the involvement of the autophagic and endo-lysosomal system and th …
A Novel Drosophila Model of Alzheimer's Disease to Study Abeta Proteotoxicity in the Digestive Tract.
Elovsson G, Klingstedt T, Brown M, Nilsson KPR, Brorsson AC. Elovsson G, et al. Int J Mol Sci. 2024 Feb 9;25(4):2105. doi: 10.3390/ijms25042105. Int J Mol Sci. 2024. PMID: 38396782 Free PMC article.
Amyloid-beta (Abeta) proteotoxicity is associated with Alzheimer's disease (AD) and is caused by protein aggregation, resulting in neuronal damage in the brain. ...
Amyloid-beta (Abeta) proteotoxicity is associated with Alzheimer's disease (AD) and is caused by protein aggregation, resulting in ne …
Proteomic signatures of Alzheimer's disease and Lewy body dementias: A comparative analysis.
Canal-Garcia A, Branca RM, Francis PT, Ballard C, Winblad B, Lehtiö J, Nilsson P, Aarsland D, Pereira JB, Bereczki E. Canal-Garcia A, et al. Alzheimers Dement. 2024 Dec 23. doi: 10.1002/alz.14375. Online ahead of print. Alzheimers Dement. 2024. PMID: 39711511
INTRODUCTION: We aimed to identify unique proteomic signatures of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Parkinson's disease dementia (PDD). METHODS: We conducted a comparative proteomic analysis of 33 post mortem brains from AD, DLB, …
INTRODUCTION: We aimed to identify unique proteomic signatures of Alzheimer's disease (AD), dementia with Lewy bodies (DLB), and Park …
Optimized sample preparation and data analysis for TMT proteomic analysis of cerebrospinal fluid applied to the identification of Alzheimer's disease biomarkers.
Weiner S, Sauer M, Visser PJ, Tijms BM, Vorontsov E, Blennow K, Zetterberg H, Gobom J. Weiner S, et al. Clin Proteomics. 2022 May 14;19(1):13. doi: 10.1186/s12014-022-09354-0. Clin Proteomics. 2022. PMID: 35568819 Free PMC article.
BACKGROUND: Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer's disease (AD). By employing tandem mass tag (TMT) proteomics, thousands of proteins can be quantified simultaneously in large cohorts, making it a …
BACKGROUND: Cerebrospinal fluid (CSF) is an important biofluid for biomarkers of neurodegenerative diseases such as Alzheimer's disea …
15 results