Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1963 1
1965 1
1966 2
1967 1
1968 3
1971 2
1972 1
1973 3
1974 3
1975 3
1976 3
1977 3
1978 5
1979 5
1980 4
1981 4
1982 6
1983 3
1984 4
1985 6
1986 3
1987 6
1988 2
1989 9
1990 3
1991 7
1992 3
1993 6
1995 8
1996 12
1997 13
1998 7
1999 8
2000 23
2001 19
2002 10
2003 13
2004 16
2005 22
2006 21
2007 27
2008 20
2009 26
2010 20
2011 21
2012 24
2013 12
2014 11
2015 17
2016 10
2017 20
2018 22
2019 27
2020 29
2021 24
2022 12
2023 18
2024 29

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

575 results

Results by year

Filters applied: . Clear all
Page 1
Kinetic studies of K-Cl cotransport in cultured rat vascular smooth muscle cells.
Lauf PK, Sharma N, Adragna NC. Lauf PK, et al. Am J Physiol Cell Physiol. 2019 Feb 1;316(2):C274-C284. doi: 10.1152/ajpcell.00002.2017. Epub 2019 Jan 16. Am J Physiol Cell Physiol. 2019. PMID: 30649919 Free article.
KCC-mediated ouabain- and bumetanide-insensitive Rb(+) (a K(+) congener) influx was determined as Cl(-)-dependent Rb(+) influx at different external Rb(+) and Cl(-) ion concentrations, [Rb(+)](o) and [Cl(-)](o). ...KCC kinetic parameters, such as maximum velocity ( V(m)), …
KCC-mediated ouabain- and bumetanide-insensitive Rb(+) (a K(+) congener) influx was determined as Cl(-)-dependent Rb(+) influx at dif …
Cibenzoline, an ATP-sensitive K(+) channel blocker, binds to the K(+)-binding site from the cytoplasmic side of gastric H(+),K(+)-ATPase.
Tabuchi Y, Yashiro H, Hoshina S, Asano S, Takeguchi N. Tabuchi Y, et al. Br J Pharmacol. 2001 Dec;134(8):1655-62. doi: 10.1038/sj.bjp.0704422. Br J Pharmacol. 2001. PMID: 11739241 Free PMC article.
The Lineweaver-Burk plot of the H(+),K(+)-ATPase activity shows that cibenzoline increases K(m) value for K(+) without affecting V(max), indicating that this drug inhibits H(+),K(+)-ATPase activity competitively with respect to K(+). 4. . …
The Lineweaver-Burk plot of the H(+),K(+)-ATPase activity shows that cibenzoline increases K(m) value for K(+) w …
Homotropic Cooperativity in Iron-Catalyzed Alkyne Cyclotrimerizations.
Geer AM, Navarro J, Alamán-Valtierra P, Coles NT, Kays DL, Tejel C. Geer AM, et al. ACS Catal. 2023 Apr 28;13(10):6610-6618. doi: 10.1021/acscatal.3c00764. eCollection 2023 May 19. ACS Catal. 2023. PMID: 37229435 Free PMC article.
Both showed sigmoidal kinetic response, with positive Hill indices of 1.85 and 3.62, respectively, and nonlinear Lineweaver-Burk replots with an upward curvature, which supports positive substrate cooperativity. ...
Both showed sigmoidal kinetic response, with positive Hill indices of 1.85 and 3.62, respectively, and nonlinear Lineweaver-Burk repl …
Kinetics of the inhibition of the Na-K pump by tetrapropylammonium chloride.
Kropp DL, Sachs JR. Kropp DL, et al. J Physiol. 1977 Jan;264(2):471-87. doi: 10.1113/jphysiol.1977.sp011678. J Physiol. 1977. PMID: 839463 Free PMC article.
The inhibitory effect of TPA on the pump rate is also promoted by external Na. 4. A Lineweaver-Burk plot of the reciprocal of the ouabain-sensitive K influx versus the reciprocal of the external K concentration is approximately a straight line if the measurem …
The inhibitory effect of TPA on the pump rate is also promoted by external Na. 4. A Lineweaver-Burk plot of the reciprocal of the oua …
JP-1366: A novel and potent potassium-competitive acid blocker that is effective in the treatment of acid-related diseases.
Ku JM, Cho JH, Kim K, Kim JY, Kim JY, Kim J, Cha H, Cheon B. Ku JM, et al. Pharmacol Res Perspect. 2023 Jun;11(3):e01090. doi: 10.1002/prp2.1090. Pharmacol Res Perspect. 2023. PMID: 37147903 Free PMC article.
We investigated whether JP-1366 affected gastric H+/K+-ATPase activity and used the Na+/K+-ATPase assay to confirm the selectivity of H+/K+-ATPase inhibition. To clarify the mechanism of enzyme inhibition, JP-1366 and TAK-438 were analyzed by Lineweaver …
We investigated whether JP-1366 affected gastric H+/K+-ATPase activity and used the Na+/K+-ATPase assay to confirm the selecti …
K(+)-H+ exchange activity in brush-border membrane vesicles isolated from chick small intestine.
Peral MJ, Cano M, Ilundáin AA. Peral MJ, et al. Eur J Biochem. 1995 Aug 1;231(3):682-6. Eur J Biochem. 1995. PMID: 7649168 Free article.
The purpose of this study was to investigate the presence of a K(+)-H+ exchanger in brush-border membrane vesicles (BBMV) isolated from chick small intestine. 86Rb+, as a tracer for K+ transport, was used to probe for the exchange mechanism. ...H(+)-driven K+ …
The purpose of this study was to investigate the presence of a K(+)-H+ exchanger in brush-border membrane vesicles (BBMV) isolated fr …
Novel indole based hybrid oxadiazole scaffolds with N-(substituted-phenyl)butanamides: synthesis, lineweaver-burk plot evaluation and binding analysis of potent urease inhibitors.
Nazir M, Abbasi MA, Aziz-Ur-Rehman, Siddiqui SZ, Raza H, Hassan M, Ali Shah SA, Shahid M, Seo SY. Nazir M, et al. RSC Adv. 2018 Jul 19;8(46):25920-25931. doi: 10.1039/c8ra04987d. eCollection 2018 Jul 19. RSC Adv. 2018. PMID: 35541970 Free PMC article.
The results of enzyme inhibitory kinetics showed that compound 8c inhibited the enzyme competitively with a K (i) value 0.003 muM. The results of the in silico study of these scaffolds were in full agreement with the experimental data and the ligands showed good binding en …
The results of enzyme inhibitory kinetics showed that compound 8c inhibited the enzyme competitively with a K (i) value 0.003 muM. Th …
Enzymatic properties and clinical associations of serum alpha-galactosidase A in Parkinson's disease.
Mizutani Y, Nawashiro K, Ohdake R, Tatebe H, Shima S, Ueda A, Yoshimoto J, Ito M, Tokuda T, Mutoh T, Watanabe H. Mizutani Y, et al. Ann Clin Transl Neurol. 2023 Sep;10(9):1662-1672. doi: 10.1002/acn3.51856. Epub 2023 Jul 26. Ann Clin Transl Neurol. 2023. PMID: 37496179 Free PMC article.
We measured serum GLA activity and calculated the apparent Michaelis constant (K(m) ) and maximal velocity (V(max) ) by Lineweaver-Burk plot analysis. Serum GLA protein concentration was measured by enzyme-linked immunosorbent assay. ...RESULTS: Compared to controls …
We measured serum GLA activity and calculated the apparent Michaelis constant (K(m) ) and maximal velocity (V(max) ) by Lineweaver …
Rolapitant Is a Reversible Inhibitor of CYP2D6.
Glass SM, Leddy SM, Orwin MC, Miller GP, Furge KA, Furge LL. Glass SM, et al. Drug Metab Dispos. 2019 Jun;47(6):567-573. doi: 10.1124/dmd.118.085928. Epub 2019 Apr 5. Drug Metab Dispos. 2019. PMID: 30952677 Free PMC article.
Stopped-flow binding studies yielded a k(on) /k(off) (K (d)) value of 6.2 M. The IC(50) value for rolapitant inhibition of CYP2D6 activity was 24 M, suggesting that inhibition is not due to tight binding of rolapitant to CYP2D6. By Lineweaver-Burk anal …
Stopped-flow binding studies yielded a k(on) /k(off) (K (d)) value of 6.2 M. The IC(50) value for rolapitant inhibition …
Enzyme kinetic parameters estimation: A tricky task?
Aledo JC. Aledo JC. Biochem Mol Biol Educ. 2021 Jul;49(4):633-638. doi: 10.1002/bmb.21522. Epub 2021 Apr 26. Biochem Mol Biol Educ. 2021. PMID: 33900008 Free article.
The aim of this paper, related to enzyme kinetics, is to illustrate how to determine the K(m) and V(max) of a michaelian enzyme avoiding the pitfalls in which we often fall. ...When these data were analyzed using conventional linear regression of double-reciprocal plots, t …
The aim of this paper, related to enzyme kinetics, is to illustrate how to determine the K(m) and V(max) of a michaelian enzyme avoid …
575 results