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PET-NECK: a multicentre randomised Phase III non-inferiority trial comparing a positron emission tomography-computerised tomography-guided watch-and-wait policy with planned neck dissection in the management of locally advanced (N2/N3) nodal metastases in patients with squamous cell head and neck cancer.
Mehanna H, McConkey CC, Rahman JK, Wong WL, Smith AF, Nutting C, Hartley AG, Hall P, Hulme C, Patel DK, Zeidler SV, Robinson M, Sanghera B, Fresco L, Dunn JA. Mehanna H, et al. Health Technol Assess. 2017 Apr;21(17):1-122. doi: 10.3310/hta21170. Health Technol Assess. 2017. PMID: 28409743 Free PMC article. Clinical Trial.
Management of Advanced Head and Neck Cancer.
Mehanna H, Wong WL, Dunn J. Mehanna H, et al. N Engl J Med. 2016 Aug 4;375(5):492-3. doi: 10.1056/NEJMc1606211. N Engl J Med. 2016. PMID: 27518680 No abstract available.
PET-CT Surveillance versus Neck Dissection in Advanced Head and Neck Cancer.
Mehanna H, Wong WL, McConkey CC, Rahman JK, Robinson M, Hartley AG, Nutting C, Powell N, Al-Booz H, Robinson M, Junor E, Rizwanullah M, von Zeidler SV, Wieshmann H, Hulme C, Smith AF, Hall P, Dunn J; PET-NECK Trial Management Group. Mehanna H, et al. N Engl J Med. 2016 Apr 14;374(15):1444-54. doi: 10.1056/NEJMoa1514493. Epub 2016 Mar 23. N Engl J Med. 2016. PMID: 27007578 Free article. Clinical Trial.
The anti-tumour activity of DNA methylation inhibitor 5-aza-2'-deoxycytidine is enhanced by the common analgesic paracetamol through induction of oxidative stress.
Gleneadie HJ, Baker AH, Batis N, Bryant J, Jiang Y, Clokie SJH, Mehanna H, Garcia P, Gendoo DMA, Roberts S, Burley M, Molinolo AA, Gutkind JS, Scheven BA, Cooper PR, Parish JL, Khanim FL, Wiench M. Gleneadie HJ, et al. Cancer Lett. 2021 Mar 31;501:172-186. doi: 10.1016/j.canlet.2020.12.029. Epub 2021 Jan 5. Cancer Lett. 2021. PMID: 33359448 Free PMC article.