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Chromosome and gene copy number variation allow major structural change between species and strains of Leishmania.
Rogers MB, Hilley JD, Dickens NJ, Wilkes J, Bates PA, Depledge DP, Harris D, Her Y, Herzyk P, Imamura H, Otto TD, Sanders M, Seeger K, Dujardin JC, Berriman M, Smith DF, Hertz-Fowler C, Mottram JC. Rogers MB, et al. Genome Res. 2011 Dec;21(12):2129-42. doi: 10.1101/gr.122945.111. Epub 2011 Oct 28. Genome Res. 2011. PMID: 22038252 Free PMC article.
Comparative genomic analysis of three Leishmania species that cause diverse human disease.
Peacock CS, Seeger K, Harris D, Murphy L, Ruiz JC, Quail MA, Peters N, Adlem E, Tivey A, Aslett M, Kerhornou A, Ivens A, Fraser A, Rajandream MA, Carver T, Norbertczak H, Chillingworth T, Hance Z, Jagels K, Moule S, Ormond D, Rutter S, Squares R, Whitehead S, Rabbinowitsch E, Arrowsmith C, White B, Thurston S, Bringaud F, Baldauf SL, Faulconbridge A, Jeffares D, Depledge DP, Oyola SO, Hilley JD, Brito LO, Tosi LR, Barrell B, Cruz AK, Mottram JC, Smith DF, Berriman M. Peacock CS, et al. Nat Genet. 2007 Jul;39(7):839-47. doi: 10.1038/ng2053. Epub 2007 Jun 17. Nat Genet. 2007. PMID: 17572675 Free PMC article.
Whole genome sequencing of multiple Leishmania donovani clinical isolates provides insights into population structure and mechanisms of drug resistance.
Downing T, Imamura H, Decuypere S, Clark TG, Coombs GH, Cotton JA, Hilley JD, de Doncker S, Maes I, Mottram JC, Quail MA, Rijal S, Sanders M, Schönian G, Stark O, Sundar S, Vanaerschot M, Hertz-Fowler C, Dujardin JC, Berriman M. Downing T, et al. Genome Res. 2011 Dec;21(12):2143-56. doi: 10.1101/gr.123430.111. Epub 2011 Oct 28. Genome Res. 2011. PMID: 22038251 Free PMC article.
Genetic markers for SSG resistance in Leishmania donovani and SSG treatment failure in visceral leishmaniasis patients of the Indian subcontinent.
Vanaerschot M, Decuypere S, Downing T, Imamura H, Stark O, De Doncker S, Roy S, Ostyn B, Maes L, Khanal B, Boelaert M, Schönian G, Berriman M, Chappuis F, Dujardin JC, Sundar S, Rijal S. Vanaerschot M, et al. J Infect Dis. 2012 Sep 1;206(5):752-5. doi: 10.1093/infdis/jis424. Epub 2012 Jun 29. J Infect Dis. 2012. PMID: 22753945 Free PMC article.