Abstract
A novel OTX-related homeodomain transcription factor has been identified on the basis of its ability to interact with the transactivation domain of the pituitary-specific POU domain protein, Pit-1. This factor, referred to as P-OTX (pituitary OTX-related factor), is expressed in primordial Rathke's pouch, oral epithelium, first bronchial arch, duodenum, and hindlimb. In the developing anterior pituitary, it is expressed in all regions from which cells with distinct phenotypes will emerge in the mature gland. P-OTX is able to independently activate and to synergize with Pit-1 on pituitary-specific target gene promoters. Therefore, P-OTX may subserve functions in generating both precursor and specific cell phenotypes in the anterior pituitary gland and in several other organs.
Publication types
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, P.H.S.
MeSH terms
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Animals
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Branchial Region / metabolism
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DNA-Binding Proteins / metabolism*
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Duodenum / metabolism
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Embryonic and Fetal Development
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Epithelium / metabolism
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Gene Expression
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Gene Expression Regulation, Developmental*
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Gene Library
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Hindlimb
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Homeodomain Proteins / biosynthesis*
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Homeodomain Proteins / metabolism
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Mice
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Molecular Sequence Data
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Organ Specificity
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Paired Box Transcription Factors
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Phenotype
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Pituitary Gland, Anterior / embryology*
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Pituitary Gland, Anterior / metabolism*
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Transcription Factor Pit-1
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Transcription Factors / metabolism*
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Transcriptional Activation
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Transfection
Substances
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DNA-Binding Proteins
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Homeodomain Proteins
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Paired Box Transcription Factors
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Pit1 protein, mouse
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Transcription Factor Pit-1
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Transcription Factors
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homeobox protein PITX1